4EEY

Crystal structure of human DNA polymerase eta in ternary complex with a cisplatin DNA adduct

Summary for 4EEY

• Entry DOI: 10.2210/pdb4eey/pdb
• Descriptor: DNA polymerase eta, 5'-D(*CP*TP*TP*GP*GP*TP*CP*TP*CP*CP*TP*CP*C)-3', 5'-D(*TP*GP*GP*AP*GP*GP*AP*GP*A)-3', ... (7 entities in total)
• Functional Keywords: dna replication, dna repair, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q9Y253
• Total number of polymer chains: 3
• Total formula weight: 56151.66

Authors

Ummat, A.,Rechkoblit, O.,Jain, R.,Choudhury, J.R.,Johnson, R.E.,Silverstein, T.D.,Buku, A.,Lone, S.,Prakash, L.,Prakash, S.,Aggarwal, A.K. (deposition date: 2012-03-28, release date: 2012-05-09, Last modification date: 2023-09-13)

• Primary citation: Ummat, A.,Rechkoblit, O.,Jain, R.,Roy Choudhury, J.,Johnson, R.E.,Silverstein, T.D.,Buku, A.,Lone, S.,Prakash, L.,Prakash, S.,Aggarwal, A.K.; Structural basis for cisplatin DNA damage tolerance by human polymerase {eta} during cancer chemotherapy.; Nat.Struct.Mol.Biol., 19:628-632, 2012; PubMed: 22562137; DOI: 10.1038/nsmb.2295

Experimental method

X-RAY DIFFRACTION (2.32 Å)