4EEY
Crystal structure of human DNA polymerase eta in ternary complex with a cisplatin DNA adduct
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA polymerase eta | polymer | 435 | 48645.8 | 1 | UniProt (Q9Y253) Pfam (PF00817) Pfam (PF21704) Pfam (PF11799) | Homo sapiens (human) | RAD30 homolog A, Xeroderma pigmentosum variant type protein |
| 2 | B (T) | 5'-D(*CP*TP*TP*GP*GP*TP*CP*TP*CP*CP*TP*CP*C)-3' | polymer | 13 | 3869.5 | 1 | |||
| 3 | C (P) | 5'-D(*TP*GP*GP*AP*GP*GP*AP*GP*A)-3' | polymer | 9 | 2844.9 | 1 | |||
| 4 | D (A) | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE | non-polymer | 467.2 | 1 | Chemie (DCP) | |||
| 5 | E (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | F (T) | Cisplatin | non-polymer | 300.0 | 1 | Chemie (CPT) | |||
| 7 | G, H, I (A, T, P) | water | water | 18.0 | 116 | Chemie (HOH) |
Sequence modifications
A: 1 - 432 (UniProt: Q9Y253)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Pro -1 | - | expression tag |
| His 0 | - | expression tag |
| Met 406 | Cys 406 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 55360.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 791.5 | |
| All* | Total formula weight | 56151.7 |
