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PDB: 68 件
6V7K
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Crystal Structure of Vascular Endothelial Growth Factor (VEGF8-109) with one copy of HH4, an alpha/beta-Peptide with Irregular Secondary Structure
分子名称: Vascular endothelial growth factor A, alpha/beta-Peptide HH4
著者Thomas, N.C, Forest, K.T, Gellman, S.H.
登録日2019-12-08
公開日2020-12-09
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献High-Resolution Structure for a Complex Between One Copy of a Non-Helical Foldamer and VEGF
to be published
4WPB
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Vascular endothelial growth factor in complex with alpha/beta-VEGF-1
分子名称: Vascular endothelial growth factor A, alpha/beta-VEGF-1
著者Kreitler, D.F, Checco, J.W, Gellman, S.H, Forest, K.T.
登録日2014-10-17
公開日2015-04-15
最終更新日2024-07-10
実験手法X-RAY DIFFRACTION (3.11 Å)
主引用文献Targeting diverse protein-protein interaction interfaces with alpha / beta-peptides derived from the Z-domain scaffold.
Proc.Natl.Acad.Sci.USA, 112, 2015
4KZN
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crystal structure of human VEGF-A receptor binding domain
分子名称: SULFATE ION, TRIETHYLENE GLYCOL, Vascular endothelial growth factor A, ...
著者Liaw, Y.C.
登録日2013-05-30
公開日2014-06-04
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.7114 Å)
主引用文献Structural Basis for the Bivalent Glycosylated Human VEGF-A121 and VEGF-A165 in recruiment of Receptor and Co-receptor
to be published
3BDY
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Dual specific bH1 Fab in complex with VEGF
分子名称: Fab Fragment -Heavy Chain, Fab Fragment -Light Chain, GLYCEROL, ...
著者Bostrom, J.M, Wiesmann, C, Appleton, B.A.
登録日2007-11-15
公開日2008-11-18
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site
Science, 323, 2009
4ZFF
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BU of 4zff by Molmil
Dual-acting Fab 5A12 in complex with VEGF
分子名称: Fragment antigen binding (Fab) 5A12 Heavy chain, Fragment antigen binding (Fab) 5A12 Light chain, SULFATE ION, ...
著者Harris, S.F, Wu, P.
登録日2015-04-21
公開日2015-07-01
最終更新日2015-09-16
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Deep Sequencing-guided Design of a High Affinity Dual Specificity Antibody to Target Two Angiogenic Factors in Neovascular Age-related Macular Degeneration.
J.Biol.Chem., 290, 2015
2C7W
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Crystal Structure of human vascular endothelial growth factor-B: Identification of amino acids important for angiogeninc activity
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, VASCULAR ENDOTHELIAL GROWTH FACTOR B PRECURSOR
著者Iyer, S, Scotney, P.D, Nash, A.D, Acharya, K.R.
登録日2005-11-29
公開日2007-01-30
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Crystal Structure of Human Vascular Endothelial Growth Factor-B: Identification of Amino Acids Important for Receptor Binding
J.Mol.Biol., 359, 2006
6T9D
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Crystal structure of a bispecific DutaFab in complex with human VEGF121
分子名称: VP mat DutaFab VH chain, VP mat DutaFab VL chain, Vascular endothelial growth factor A
著者Kimbung, R, Logan, D.T, Beckmann, R, Jensen, K, Speck, J, Fenn, S, Kettenberger, H.
登録日2019-10-28
公開日2020-12-16
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.905 Å)
主引用文献DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously.
Nat Commun, 12, 2021
6D3O
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Crystal Structure of Vascular Endothelial Growth Factor (VEGF8-109) with HH4, an alpha/beta-Peptide with Irregular Secondary Structure
分子名称: HH4 alpha/beta-Peptide, Vascular endothelial growth factor A
著者Thomas, N.C, Forest, K.T, Gellman, S.H.
登録日2018-04-16
公開日2019-04-24
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献High-Resolution Structures for a Complex Between a Non-Helical Foldamer and VEGF
To Be Published
6T9E
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Crystal structure of a bispecific DutaFab in complex with human PDGF
分子名称: DutaFab mat VH chain, DutaFab mat VL chain, Platelet-derived growth factor subunit B
著者Kimbung, R, Logan, D.T, Beckmann, R, Jensen, K, Speck, J, Fenn, S, Kettenberger, H.
登録日2019-10-28
公開日2020-12-16
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.989 Å)
主引用文献DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously.
Nat Commun, 12, 2021
1FZV
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THE CRYSTAL STRUCTURE OF HUMAN PLACENTA GROWTH FACTOR-1 (PLGF-1), AN ANGIOGENIC PROTEIN AT 2.0A RESOLUTION
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, PLACENTA GROWTH FACTOR
著者Iyer, S, Leonidas, D.D, Swaminathan, G.J, Maglione, D, Battisti, M, Tucci, M, Persico, M.G, Acharya, K.R.
登録日2000-10-04
公開日2001-05-09
最終更新日2022-12-21
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution.
J.Biol.Chem., 276, 2001
4QCI
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PDGF-B blocking antibody bound to PDGF-BB
分子名称: Platelet-derived growth factor subunit B, anti-PDGF-BB antibody - Light Chain, anti-PDGF-BB antibody - Heavy chain
著者Kuai, J, Mosyak, L, Tam, M, LaVallie, E, Pullen, N, Carven, G.
登録日2014-05-12
公開日2015-03-11
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Characterization of Binding Mode of Action of a Blocking Anti-Platelet-Derived Growth Factor (PDGF)-B Monoclonal Antibody, MOR8457, Reveals Conformational Flexibility and Avidity Needed for PDGF-BB To Bind PDGF Receptor-beta.
Biochemistry, 54, 2015
1KAT
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BU of 1kat by Molmil
Solution Structure of a Phage-Derived Peptide Antagonist in Complex with Vascular Endothelial Growth Factor
分子名称: Phage-Derived Peptide Antagonist, Vascular Endothelial Growth Factor
著者Pan, B, Li, B, Russell, S.J, Tom, J.Y.K, Cochran, A.G, Fairbrother, W.J.
登録日2001-11-02
公開日2002-11-02
最終更新日2022-02-23
実験手法SOLUTION NMR
主引用文献Solution Structure of a Phage-derived Peptide Antagonist in Complex with Vascular Endothelial Growth Factor
J.Mol.Biol., 316, 2002
1MJV
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DISULFIDE DEFICIENT MUTANT OF VASCULAR ENDOTHELIAL GROWTH FACTOR A (C51A and C60A)
分子名称: Vascular Endothelial Growth Factor A
著者Muller, Y.A, Heiring, C, Misselwitz, R, Welfle, K, Welfle, H.
登録日2002-08-28
公開日2002-12-11
最終更新日2021-10-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor
J.Biol.Chem., 277, 2002
1BJ1
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VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH A NEUTRALIZING ANTIBODY
分子名称: Fab fragment, heavy chain, light chain, ...
著者Muller, Y.A, Christinger, H.W, De Vos, A.M.
登録日1998-06-30
公開日1999-01-13
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface.
Structure, 6, 1998
1MKK
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Disulfide deficient mutant of vascular endothelial growth factor A (C61A and C104A)
分子名称: Vascular Endothelial Growth Factor A
著者Muller, Y.A, Heiring, C, Misselwitz, R, Welfle, K, Welfle, H.
登録日2002-08-29
公開日2002-12-11
最終更新日2021-10-27
実験手法X-RAY DIFFRACTION (1.32 Å)
主引用文献The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor
J.Biol.Chem., 277, 2002
2QR0
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BU of 2qr0 by Molmil
Structure of VEGF complexed to a Fab containing TYR and SER in the CDRs
分子名称: Fab-Fragment Heavy Chain, Fab-Fragment Light Chain, Vascular endothelial growth factor A
著者Wiesmann, C.
登録日2007-07-27
公開日2007-08-14
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries
J.Mol.Biol., 373, 2007
2FJH
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BU of 2fjh by Molmil
Structure of the B20-4 Fab, a phage derived Fab fragment, in complex with VEGF
分子名称: Fab fragment heavy chain, Fab fragment light chain, Vascular endothelial growth factor A
著者Wiesmann, C.
登録日2006-01-02
公開日2006-02-07
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.
J.Biol.Chem., 281, 2006
2FJG
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BU of 2fjg by Molmil
Structure of the G6 Fab, a phage derived Fab fragment, in complex with VEGF
分子名称: Fab heavy chain, Fab light chain, SULFATE ION, ...
著者Wiesmann, C.
登録日2006-01-02
公開日2006-02-07
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.
J.Biol.Chem., 281, 2006
2GNN
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BU of 2gnn by Molmil
Crystal Structure of the Orf Virus NZ2 Variant of VEGF-E
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, BENZAMIDINE, ...
著者Prota, A.E, Pieren, M, Wagner, A, Kostrewa, D, Winkler, F.K, Ballmer-Hofer, K.
登録日2006-04-10
公開日2006-05-09
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the Orf virus NZ2 variant of vascular endothelial growth factor-E. Implications for receptor specificity.
J.Biol.Chem., 281, 2006
2VPF
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VASCULAR ENDOTHELIAL GROWTH FACTOR REFINED TO 1.93 ANGSTROMS RESOLUTION
分子名称: VASCULAR ENDOTHELIAL GROWTH FACTOR
著者Muller, Y.A, De Vos, A.M.
登録日1997-07-29
公開日1998-07-29
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 A resolution: multiple copy flexibility and receptor binding.
Structure, 5, 1997
1MKG
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DISULFIDE DEFICIENT MUTANT OF VASCULAR ENDOTHELIAL GROWTH FACTOR A (C57A and C102A)
分子名称: Vascular Endothelial Growth Factor A
著者Muller, Y.A, Heiring, C, Misselwitz, R, Welfle, K, Welfle, H.
登録日2002-08-29
公開日2002-12-11
最終更新日2021-10-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor
J.Biol.Chem., 277, 2002
2VWE
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Crystal Structure of Vascular Endothelial Growth Factor-B in Complex with a Neutralizing Antibody Fab Fragment
分子名称: ANTI-VEGF-B MONOCLONAL ANTIBODY, VASCULAR ENDOTHELIAL GROWTH FACTOR B
著者Leonard, P, Scotney, P.D, Jabeen, T, Iyer, S, Fabri, L.J, Nash, A.D, Acharya, K.R.
登録日2008-06-23
公開日2008-11-04
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Crystal Structure of Vascular Endothelial Growth Factor-B in Complex with a Neutralising Antibody Fab Fragment.
J.Mol.Biol., 384, 2008
1CZ8
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VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY
分子名称: HEAVY CHAIN OF NEUTRALIZING ANTIBODY, LIGHT CHAIN OF NEUTRALIZING ANTIBODY, SULFATE ION, ...
著者Chen, Y, Wiesmann, C, Fuh, G, Li, B, Christinger, H.W, McKay, P, de Vos, A.M, Lowman, H.B.
登録日1999-09-01
公開日2000-03-20
最終更新日2017-04-05
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen.
J.Mol.Biol., 293, 1999
1WQ8
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Crystal structure of Vammin, a VEGF-F from a snake venom
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Vascular endothelial growth factor toxin
著者Suto, K, Yamazaki, Y, Morita, T, Mizuno, H.
登録日2004-09-23
公開日2004-12-07
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structures of novel vascular endothelial growth factors (VEGF) from snake venoms: insight into selective VEGF binding to kinase insert domain-containing receptor but not to fms-like tyrosine kinase-1.
J.Biol.Chem., 280, 2005
3P9W
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Crystal structure of an engineered human autonomous VH Domain in complex with VEGF
分子名称: Vascular endothelial growth factor A, human VEGF
著者Ma, X, Wiesmann, C.
登録日2010-10-18
公開日2012-04-18
最終更新日2013-06-19
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Design of Synthetic Autonomous VH Domain Libraries and Structural Analysis of a VH Domain Bound to Vascular Endothelial Growth Factor.
J.Mol.Biol., 425, 2013

 

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