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PDB: 307 件

4TTH
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Crystal structure of a CDK6/Vcyclin complex with inhibitor bound
分子名称: 9-cyclopentyl-N-(5-piperazin-1-ylpyridin-2-yl)pyrido[4,5]pyrrolo[1,2-d]pyrimidin-2-amine, Cyclin homolog, Cyclin-dependent kinase 6
著者Piper, D.E, Walker, N, Wang, Z.
登録日2014-06-20
公開日2014-08-06
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.
J.Med.Chem., 57, 2014
3BLQ
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Crystal Structure of Human CDK9/cyclinT1 in Complex with ATP
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-TRIPHOSPHATE, Cell division protein kinase 9, ...
著者Baumli, S, Lolli, G, Lowe, E.D, Johnson, L.N.
登録日2007-12-11
公開日2008-07-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation
Embo J., 27, 2008
4FX3
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BU of 4fx3 by Molmil
Crystal Structure of the CDK2/Cyclin A complex with oxindole inhibitor
分子名称: (3Z)-2-oxo-3-[2-(4-sulfamoylphenyl)hydrazinylidene]-2,3-dihydro-1H-indole-5-carboxylic acid, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Cyclin-A2, ...
著者Kang, Y.N, Stuckey, J.A.
登録日2012-07-02
公開日2013-05-15
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Crystal Structure of the CDK2/Cyclin A complex with oxindole inhibitor
To be Published
6RIJ
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CDK2/cyclin A2 in complex with open-ring 5-nitrosopyrimidine inhibitor LC436
分子名称: 4-[[[5-nitroso-2-[[(2~{R})-1-oxidanylbutan-2-yl]amino]-6-(propan-2-ylamino)pyrimidin-4-yl]amino]methyl]phenol, Cyclin-A2, Cyclin-dependent kinase 2, ...
著者Skerlova, J, Rezacova, P, Brynda, J.
登録日2019-04-24
公開日2020-07-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献CDK2/cyclin A2 in complex with open-ring 5-nitrosopyrimidine inhibitor LC436
To Be Published
3QHW
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Structure of a pCDK2/CyclinA transition-state mimic
分子名称: (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, ADENOSINE-5'-DIPHOSPHATE, CDK2 substrate peptide: PKTPKKAKKL, ...
著者Young, M.A, Jacobsen, D.M, Bao, Z.Q.
登録日2011-01-26
公開日2011-05-25
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Briefly Bound to Activate: Transient Binding of a Second Catalytic Magnesium Activates the Structure and Dynamics of CDK2 Kinase for Catalysis.
Structure, 19, 2011
3LQ5
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BU of 3lq5 by Molmil
Structure of CDK9/CyclinT in complex with S-CR8
分子名称: (2S)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol, Cell division protein kinase 9, Cyclin-T1
著者Hole, A.J, Endicott, J.A, Baumli, S.
登録日2010-02-08
公開日2011-01-19
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells
Genes Cancer, 1, 2010
4G6L
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BU of 4g6l by Molmil
Crystal structure of human CDK8/CYCC in the DMG-in conformation
分子名称: Cyclin-C, Cyclin-dependent kinase 8, FORMIC ACID
著者Schneider, E.V, Blaesse, M, Huber, R, Maskos, K.
登録日2012-07-19
公開日2013-05-01
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure-kinetic relationship study of CDK8/CycC specific compounds.
Proc.Natl.Acad.Sci.USA, 110, 2013
3MI9
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Crystal structure of HIV-1 Tat complexed with human P-TEFb
分子名称: Cell division protein kinase 9, Cyclin-T1, Protein Tat, ...
著者Tahirov, T.H, Babayeva, N.D, Varzavand, K, Cooper, J.J, Sedore, S.C, Price, D.H.
登録日2010-04-09
公開日2010-06-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of HIV-1 Tat complexed with human P-TEFb.
Nature, 465, 2010
1JST
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PHOSPHORYLATED CYCLIN-DEPENDENT KINASE-2 BOUND TO CYCLIN A
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CYCLIN A, CYCLIN-DEPENDENT KINASE-2, ...
著者Russo, A.A, Jeffrey, P.D, Pavletich, N.P.
登録日1996-07-03
公開日1997-01-11
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis of cyclin-dependent kinase activation by phosphorylation.
Nat.Struct.Biol., 3, 1996
1JSU
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P27(KIP1)/CYCLIN A/CDK2 COMPLEX
分子名称: CYCLIN A, CYCLIN-DEPENDENT KINASE-2, P27, ...
著者Russo, A.A, Jeffrey, P.D, Pavletich, N.P.
登録日1996-07-03
公開日1997-07-29
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.
Nature, 382, 1996
6T41
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CDK8/Cyclin C in complex with N-(4-chlorobenzyl)isoquinolin-4-amine
分子名称: 1,2-ETHANEDIOL, Cyclin-C, Cyclin-dependent kinase 8, ...
著者Schneider, E.V, Maskos, K, Huber, R, Kuhn, C.-D.
登録日2019-10-11
公開日2020-01-01
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献A precisely positioned MED12 activation helix stimulates CDK8 kinase activity.
Proc.Natl.Acad.Sci.USA, 117, 2020
3MIA
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BU of 3mia by Molmil
Crystal structure of HIV-1 Tat complexed with ATP-bound human P-TEFb
分子名称: Cell division protein kinase 9, Cyclin-T1, MAGNESIUM ION, ...
著者Tahirov, T.H, Babayeva, N.D, Varzavand, K, Cooper, J.J, Sedore, S.C, Price, D.H.
登録日2010-04-09
公開日2010-06-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal structure of HIV-1 Tat complexed with human P-TEFb.
Nature, 465, 2010
6TPA
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CDK8/CyclinC in complex with drug ETP-50775
分子名称: (2~{R})-butane-1,2-diol, 1-[4-chloranyl-3-(trifluoromethyl)phenyl]-3-(5-oxidanylidene-6-pyridin-4-yl-pyrido[2,3-b][1,5]benzoxazepin-9-yl)urea, Cyclin-C, ...
著者Munoz, I.G, Pastor, J, Martinez, S.
登録日2019-12-12
公開日2020-11-18
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Pyrido[2,3-b][1,5]benzoxazepin-5(6H)-one derivatives as CDK8 inhibitors.
Eur.J.Med.Chem., 201, 2020
7KPX
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BU of 7kpx by Molmil
Structure of the yeast CKM
分子名称: Mediator of RNA polymerase II transcription subunit 12, Mediator of RNA polymerase II transcription subunit 13, Meiotic mRNA stability protein kinase SSN3, ...
著者Li, Y.C, Chao, T.C, Kim, H.J, Cholko, T, Chen, S.F, Nakanishi, K, Chang, C.E, Murakami, K, Garcia, B.A, Boyer, T.G, Tsai, K.L.
登録日2020-11-12
公開日2021-01-27
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module.
Sci Adv, 7, 2021
7KPV
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Structure of kinase and Central lobes of yeast CKM
分子名称: Mediator of RNA polymerase II transcription subunit 12, Mediator of RNA polymerase II transcription subunit 13, Meiotic mRNA stability protein kinase SSN3, ...
著者Li, Y.C, Chao, T.C, Kim, H.J, Cholko, T, Chen, S.F, Nakanishi, K, Chang, C.E, Murakami, K, Garcia, B.A, Boyer, T.G, Tsai, K.L.
登録日2020-11-12
公開日2021-01-27
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module.
Sci Adv, 7, 2021
6SG4
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BU of 6sg4 by Molmil
Structure of CDK2/cyclin A M246Q, S247EN
分子名称: Cyclin-A2, Cyclin-dependent kinase 2
著者Salamina, M, Basle, A, Massa, B, Noble, M.E.M, Endicott, J.A.
登録日2019-08-02
公開日2021-01-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation.
J.Mol.Biol., 433, 2021
4I3Z
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BU of 4i3z by Molmil
Structure of pCDK2/CyclinA bound to ADP and 2 Magnesium ions
分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Cyclin-A2, ...
著者Jacobsen, D.M, Bao, Z.-Q, O'Brien, P.J, Brooks, C.L, Young, M.A.
登録日2012-11-27
公開日2012-12-26
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Price To Be Paid for Two-Metal Catalysis: Magnesium Ions That Accelerate Chemistry Unavoidably Limit Product Release from a Protein Kinase
J.Am.Chem.Soc., 134, 2012
3MY5
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BU of 3my5 by Molmil
CDk2/cyclinA in complex with DRB
分子名称: 5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole, Cell division protein kinase 2, Cyclin-A2, ...
著者Baumli, S, Johnson, L.N.
登録日2010-05-09
公開日2010-09-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Halogen bonds form the basis for selective P-TEFb inhibition by DRB
Chem.Biol., 17, 2010
6TD3
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Structure of DDB1 bound to CR8-engaged CDK12-cyclinK
分子名称: (2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ...
著者Bunker, R.D, Petzold, G, Kozicka, Z, Thoma, N.H.
登録日2019-11-07
公開日2020-06-17
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.46 Å)
主引用文献The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K.
Nature, 585, 2020
7JV7
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BU of 7jv7 by Molmil
Crystal Structure of the yeast RNA Pol II CTD kinase CTDK-1 complex
分子名称: CITRATE ANION, CTD kinase subunit alpha, CTD kinase subunit beta, ...
著者Xie, Y, Ren, Y.
登録日2020-08-20
公開日2021-01-27
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.850553 Å)
主引用文献Structure and activation mechanism of the yeast RNA Pol II CTD kinase CTDK-1 complex.
Proc.Natl.Acad.Sci.USA, 118, 2021
7KUE
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CryoEM structure of Yeast TFIIK (Kin28/Ccl1/Tfb3) Complex
分子名称: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Cyclin CCL1, ...
著者van Eeuwen, T, Murakami, K, Li, T, Tsai, K.L.
登録日2020-11-24
公開日2021-04-28
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structure of TFIIK for phosphorylation of CTD of RNA polymerase II.
Sci Adv, 7, 2021
3RGF
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Crystal Structure of human CDK8/CycC
分子名称: 1,2-ETHANEDIOL, 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, Cyclin-C, ...
著者Schneider, E.V, Boettcher, J, Blaesse, M, Huber, R, Maskos, K.
登録日2011-04-08
公開日2011-08-10
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The Structure of CDK8/CycC Implicates Specificity in the CDK/Cyclin Family and Reveals Interaction with a Deep Pocket Binder.
J.Mol.Biol., 412, 2011
7KJS
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Crystal structure of CDK2/cyclin E in complex with PF-06873600
分子名称: 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-{[1-(methylsulfonyl)piperidin-4-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1
著者McTigue, M.A, He, Y, Ferre, R.A.
登録日2020-10-26
公開日2021-06-23
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.187 Å)
主引用文献Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer.
J.Med.Chem., 64, 2021
4II5
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Structure of PCDK2/CYCLINA bound to ADP and 1 MAGNESIUM ION
分子名称: ADENOSINE-5'-DIPHOSPHATE, Cyclin-A2, Cyclin-dependent kinase 2, ...
著者Jacobsen, D.M, Bao, Z.-Q, O'Brien, P.J, Brooks III, C.L, Young, M.A.
登録日2012-12-19
公開日2013-01-23
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Price to be paid for two-metal catalysis: Magnesium ions that accelerate chemistry unavoidably limit product release from a PROTEIN KINASE
J.Am.Chem.Soc., 134, 2012
4IMY
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The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat
分子名称: ADENOSINE MONOPHOSPHATE, AF4/FMR2 family member 4, Cyclin-T1, ...
著者Alber, T, Schulze-Gahmen, U.
登録日2013-01-03
公開日2013-03-13
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.94 Å)
主引用文献The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat.
Elife, 2, 2013

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