6GUB

CDK2/CyclinA in complex with Flavopiridol

Summary for 6GUB

Entry DOI	10.2210/pdb6gub/pdb
Descriptor	Cyclin-dependent kinase 2, Cyclin-A2, 2-(2-chlorophenyl)-8-[(3~{R},4~{R})-1-methyl-3-oxidanyl-piperidin-4-yl]-5,7-bis(oxidanyl)chromen-4-one, ... (4 entities in total)
Functional Keywords	cdk2, cyclina, inhibitor, cell cycle
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	131148.17
Authors	Wood, D.J.,Korolchuk, S.,Tatum, N.J.,Wang, L.Z.,Endicott, J.A.,Noble, M.E.M.,Martin, M.P. (deposition date: 2018-06-19, release date: 2018-12-05, Last modification date: 2024-01-17)
Primary citation	Wood, D.J.,Korolchuk, S.,Tatum, N.J.,Wang, L.Z.,Endicott, J.A.,Noble, M.E.M.,Martin, M.P. Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition. Cell Chem Biol, 26:121-130.e5, 2019 Cited by PubMed: 30472117 DOI: 10.1016/j.chembiol.2018.10.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.52 Å)

Structure validation