4IMY

The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat

Summary for 4IMY

• Entry DOI: 10.2210/pdb4imy/pdb
• Descriptor: Cyclin-dependent kinase 9, Cyclin-T1, AF4/FMR2 family member 4, ... (5 entities in total)
• Functional Keywords: transcriptional cdk9-cyct1 complex, phosphorylated, intrinsically disordered aff4, regulation of transcription elongation, ser/thr kinase, phosphorylation of polii-ctd, dsif, and nelf, hiv-1 tat, host-virus interaction, phosphoprotein, nucleus, transferase
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P50750 O60563 Q9UHB7
• Total number of polymer chains: 9
• Total formula weight: 233946.80

Authors

Alber, T.,Schulze-Gahmen, U. (deposition date: 2013-01-03, release date: 2013-03-13, Last modification date: 2023-09-20)

• Primary citation: Schulze-Gahmen, U.,Upton, H.,Birnberg, A.,Bao, K.,Chou, S.,Krogan, N.J.,Zhou, Q.,Alber, T.; The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat.; Elife, 2:e00327-e00327, 2013; PubMed: 23471103; DOI: 10.7554/eLife.00327

Experimental method

X-RAY DIFFRACTION (2.94 Å)