4IMY
The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E | Cyclin-dependent kinase 9 | polymer | 332 | 38226.3 | 3 | UniProt (P50750) Pfam (PF00069) In PDB | Homo sapiens (human) | C-2K, Cell division cycle 2-like protein kinase 4, Cell division protein kinase 9, Serine/threonine-protein kinase PITALRE, Tat-associated kinase complex catalytic subunit |
| 2 | B, D, F | Cyclin-T1 | polymer | 264 | 30619.0 | 3 | UniProt (O60563) Pfam (PF00134) Pfam (PF21797) In PDB | Homo sapiens (human) | CycT1, Cyclin-T |
| 3 | G, H, I | AF4/FMR2 family member 4 | polymer | 75 | 8789.8 | 3 | UniProt (Q9UHB7) In PDB | Homo sapiens (human) | ALL1-fused gene from chromosome 5q31 protein, Protein AF-5q31, Major CDK9 elongation factor-associated protein |
| 4 | A, C, E | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 3 | Chemie (AMP) | |||
| 5 | water | water | 18.0 | 19 | Chemie (HOH) |
Sequence modifications
A, C, E: 1 - 330 (UniProt: P50750)
G, H, I: 2 - 73 (UniProt: Q9UHB7)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| His 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Asn 0 | - | expression tag |
| Ala 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 232905.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1041.7 | |
| All* | Total formula weight | 233946.8 |
