7B5Q

Cryo-EM structure of the human CAK bound to ICEC0942 (PHENIX-OPLS3e)

Summary for 7B5Q

• Entry DOI: 10.2210/pdb7b5q/pdb
• EMDB information: 11823 11828 12042
• Descriptor: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... (5 entities in total)
• Functional Keywords: kinase, protein complex, small molecules inhibitor, cdk-activating kinase, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 119873.40

Authors

Greber, B.J.,Remis, J.,Ali, S.,Nogales, E. (deposition date: 2020-12-05, release date: 2021-02-10, Last modification date: 2021-03-03)

• Primary citation: Greber, B.J.,Remis, J.,Ali, S.,Nogales, E.; 2.5 angstrom -resolution structure of human CDK-activating kinase bound to the clinical inhibitor ICEC0942.; Biophys.J., 120:677-686, 2021; PubMed: 33476598; DOI: 10.1016/j.bpj.2020.12.030

Experimental method

ELECTRON MICROSCOPY (2.5 Å)