6XD3

Structure of the human CAK in complex with THZ1

Summary for 6XD3

• Entry DOI: 10.2210/pdb6xd3/pdb
• Related: 6XBZ
• EMDB information: 22123 22131
• Descriptor: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... (4 entities in total)
• Functional Keywords: kinase, transcription, cell cycle, complex, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 87940.65

Authors

Greber, B.J.,Perez-Bertoldi, J.M.,Lim, K.,Iavarone, A.T.,Toso, D.B.,Nogales, E. (deposition date: 2020-06-09, release date: 2020-09-09, Last modification date: 2020-09-30)

• Primary citation: Greber, B.J.,Perez-Bertoldi, J.M.,Lim, K.,Iavarone, A.T.,Toso, D.B.,Nogales, E.; The cryoelectron microscopy structure of the human CDK-activating kinase.; Proc.Natl.Acad.Sci.USA, 117:22849-22857, 2020; PubMed: 32855301; DOI: 10.1073/pnas.2009627117

Experimental method

ELECTRON MICROSCOPY (3.3 Å)