6XD3

Structure of the human CAK in complex with THZ1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	H	CDK-activating kinase assembly factor MAT1	polymer	93	10234.5	1	UniProt (P51948) In PDB	Homo sapiens (Human)	CDK7/cyclin-H assembly factor,Cyclin-G1-interacting protein,Menage a trois,RING finger protein 66,RING finger protein MAT1,p35,p36
2	I	Cyclin-H	polymer	323	37695.5	1	UniProt (P51946) Pfam (PF00134) Pfam (PF16899) In PDB	Homo sapiens (Human)	MO15-associated protein,p34,p37
3	J	Cyclin-dependent kinase 7	polymer	349	39442.6	1	UniProt (P50613) Pfam (PF00069) In PDB	Homo sapiens (Human)	39 kDa protein kinase,p39 Mo15,CDK-activating kinase 1,Cell division protein kinase 7,Serine/threonine-protein kinase 1,TFIIH basal transcription factor complex kinase subunit
4	J	N-(3-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)-4-{[4-(dimethylamino)butanoyl]amino}benzamide	non-polymer		568.1	1	Chemie (V0G)

Sequence modifications

H: 220 - 309 (UniProt: P51948)

PDB	External Database	Details
Ser 217	-	expression tag
Asn 218	-	expression tag
Ala 219	-	expression tag

J: 1 - 346 (UniProt: P50613)

PDB	External Database	Details
Ser -2	-	expression tag
Asn -1	-	expression tag
Ala 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	87372.6
Non-Polymers*	Number of molecules	1
	Total formula weight	568.1
All*	Total formula weight	87940.6

*Water molecules are not included.