1TKN
 
 | | Solution structure of CAPPD*, an independently folded extracellular domain of human Amyloid-beta Precursor Protein | | 分子名称: | Amyloid beta A4 protein | | 著者 | Dulubova, I, Ho, A, Huryeva, I, Sudhof, T.C, Rizo, J. | | 登録日 | 2004-06-08 | | 公開日 | 2004-08-03 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Three-dimensional structure of an independently folded extracellular domain of human amyloid-beta precursor protein.
Biochemistry, 43, 2004
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7JXN
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6SZF
 | | Solution structure of the amyloid beta-peptide (1-42) | | 分子名称: | Amyloid-beta precursor protein | | 著者 | Grimaldi, M, Santoro, A, Stillitano, I, Buonocore, M, D'Ursi, A.M. | | 登録日 | 2019-10-02 | | 公開日 | 2020-10-14 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Exploring the Early Stages of the Amyloid A beta (1-42) Peptide Aggregation Process: An NMR Study.
Pharmaceuticals, 14, 2021
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7OW1
 | | Crystal Structure of TAP01 in complex with amyloid beta peptide | | 分子名称: | Amyloid-beta precursor protein, CITRATE ANION, TAP01 family antibody heavy chain, ... | | 著者 | Hall, G, Cowan, R, Carr, M.D. | | 登録日 | 2021-06-16 | | 公開日 | 2022-06-29 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Discovery of a novel pseudo beta-hairpin structure of N-truncated amyloid-beta for use as a vaccine against Alzheimer's disease.
Mol Psychiatry, 27, 2022
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3GCI
 | | Crystal Structure of the Complex Formed Between a New Isoform of Phospholipase A2 with C-terminal Amyloid Beta Heptapeptide at 2 A Resolution | | 分子名称: | CALCIUM ION, Heptapeptide from Amyloid beta A4 protein, Phospholipase A2 isoform 3 | | 著者 | Mirza, Z, Vikram, G, Singh, N, Sinha, M, Bhushan, A, Sharma, S, Srinivasan, A, Kaur, P, Singh, T.P. | | 登録日 | 2009-02-22 | | 公開日 | 2009-03-10 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | Crystal Structure of the Complex Formed Between a New Isoform of Phospholipase A2 with C-terminal Amyloid Beta Heptapeptide at 2 A Resolution
To be Published
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7OXN
 | | Crystal Structure of TAP01 in complex with cyclised amyloid beta peptide | | 分子名称: | 1,2-ETHANEDIOL, Amyloid-beta precursor protein, TAP01 family antibody heavy chain, ... | | 著者 | Hall, G, Cowan, R, Carr, M.D. | | 登録日 | 2021-06-22 | | 公開日 | 2022-06-29 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Discovery of a novel pseudo beta-hairpin structure of N-truncated amyloid-beta for use as a vaccine against Alzheimer's disease.
Mol Psychiatry, 27, 2022
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3DXC
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3DXD
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7Q4M
 | | Type II beta-amyloid 42 Filaments from Human Brain | | 分子名称: | Amyloid-beta precursor protein, UNKNOWN ATOM OR ION | | 著者 | Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M. | | 登録日 | 2021-11-01 | | 公開日 | 2021-11-24 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Cryo-EM structures of amyloid-beta 42 filaments from human brains.
Science, 375, 2022
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7Q4B
 | | Type I beta-amyloid 42 Filaments from Human Brain | | 分子名称: | Amyloid-beta precursor protein, UNKNOWN ATOM OR ION | | 著者 | Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M. | | 登録日 | 2021-10-30 | | 公開日 | 2021-11-24 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Cryo-EM structures of amyloid-beta 42 filaments from human brains.
Science, 375, 2022
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7Y8Q
 | | Amyloid-beta assemblage on GM1-containing membranes | | 分子名称: | Amyloid-beta protein 40 | | 著者 | Yagi-Utsumi, M, Itoh, S.G, Okumura, H, Yanagisawa, K, Kato, K, Nishimura, K. | | 登録日 | 2022-06-24 | | 公開日 | 2023-07-05 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLID-STATE NMR | | 主引用文献 | The Double-Layered Structure of Amyloid-beta Assemblage on GM1-Containing Membranes Catalytically Promotes Fibrillization.
Acs Chem Neurosci, 14, 2023
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3DXE
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6TI5
 | | A New Structural Model of Abeta(1-40) Fibrils | | 分子名称: | Amyloid-beta precursor protein | | 著者 | Bertini, I, Gonnelli, L, Luchinat, C, Mao, J, Nesi, A. | | 登録日 | 2019-11-21 | | 公開日 | 2020-07-22 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLID-STATE NMR | | 主引用文献 | Mixing A beta (1-40) and A beta (1-42) peptides generates unique amyloid fibrils.
Chem.Commun.(Camb.), 56, 2020
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6TI6
 | | Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils | | 分子名称: | Amyloid-beta precursor protein | | 著者 | Cerofolini, L, Ravera, E, Bologna, S, Wiglenda, T, Boddrich, A, Purfurst, B, Benilova, A, Korsak, M, Gallo, G, Rizzo, D, Gonnelli, L, Fragai, M, De Strooper, B, Wanker, E.E, Luchinat, C. | | 登録日 | 2019-11-21 | | 公開日 | 2020-07-22 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLID-STATE NMR | | 主引用文献 | Mixing A beta (1-40) and A beta (1-42) peptides generates unique amyloid fibrils.
Chem.Commun.(Camb.), 56, 2020
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6TI7
 | | Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils | | 分子名称: | Amyloid-beta precursor protein | | 著者 | Cerofolini, L, Ravera, E, Bologna, S, Wiglenda, T, Boddrich, A, Purfurst, B, Benilova, A, Korsak, M, Gallo, G, Rizzo, D, Gonnelli, L, Fragai, M, De Strooper, B, Wanker, E.E, Luchinat, C. | | 登録日 | 2019-11-21 | | 公開日 | 2020-07-22 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLID-STATE NMR | | 主引用文献 | Mixing A beta (1-40) and A beta (1-42) peptides generates unique amyloid fibrils.
Chem.Commun.(Camb.), 56, 2020
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7WVY
 | | Cryo-EM structure of the human formyl peptide receptor 2 in complex with Abeta42 and Gi2 | | 分子名称: | Amyloid-beta A4 protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2022-02-11 | | 公開日 | 2022-04-13 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
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6W0O
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5AM8
 | | Crystal structure of the Angiotensin-1 converting enzyme N-domain in complex with amyloid-beta 4-10 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANGIOTENSIN-CONVERTING ENZYME, ... | | 著者 | Masuyer, G, Larmuth, K.M, Douglas, R.G, Sturrock, E.D, Acharya, K.R. | | 登録日 | 2015-03-10 | | 公開日 | 2016-01-13 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The Kinetic and Structural Characterisation of Amyloid-Beta Metabolism by Human Angiotensin-1- Converting Enzyme (Ace)
FEBS J., 283, 2016
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5C67
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5CSZ
 | | CRYSTAL STRUCTURE OF GANTENERUMAB FAB FRAGMENT IN COMPLEX WITH ABETA 1-11 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Amyloid beta A4 protein, GANTENERUMAB FAB FRAGMENT HEAVY CHAIN, ... | | 著者 | Benz, J, Burger, D, Loetscher, H.R, Bohrmann, B. | | 登録日 | 2015-07-23 | | 公開日 | 2015-08-12 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Gantenerumab: a novel human anti-Abeta antibody demonstrates sustained cerebral amyloid-Beta binding and elicits cell-mediated removal of human amyloid-Beta.
J. Alzheimers Dis., 28, 2012
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5AMB
 | | Crystal structure of the Angiotensin-1 converting enzyme N-domain in complex with amyloid-beta 35-42 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AMYLOID BETA A4 PROTEIN, ANGIOTENSIN-CONVERTING ENZYME, ... | | 著者 | Masuyer, G, Larmuth, K.M, Douglas, R.G, Sturrock, E.D, Acharya, K.R. | | 登録日 | 2015-03-10 | | 公開日 | 2016-01-13 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | The Kinetic and Structural Characterisation of Amyloid-Beta Metabolism by Human Angiotensin-1- Converting Enzyme (Ace)
FEBS J., 283, 2016
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5BUO
 | | A receptor molecule | | 分子名称: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ACETATE ION, Amyloid beta A4 protein, ... | | 著者 | Gao, C, Crespi, G.A.N, Gorman, M.A, Nero, T.L, Parker, M.W, Miles, L.A. | | 登録日 | 2015-06-04 | | 公開日 | 2016-07-13 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | NULL
To Be Published
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1ZE7
 | | Zinc-binding domain of Alzheimer's disease amyloid beta-peptide in water solution at pH 6.5 | | 分子名称: | 16-mer from Alzheimer's disease amyloid Protein | | 著者 | Zirah, S, Kozin, S.A, Mazur, A.K, Blond, A, Cheminant, M, Segalas-Milazzo, I, Debey, P, Rebuffat, S. | | 登録日 | 2005-04-18 | | 公開日 | 2005-05-03 | | 最終更新日 | 2013-10-09 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural changes of region 1-16 of the Alzheimer disease amyloid beta-peptide upon zinc binding and in vitro aging.
J.Biol.Chem., 281, 2006
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1ZE9
 | | Zinc-binding domain of Alzheimer's disease amyloid beta-peptide complexed with a zinc (II) cation | | 分子名称: | 16-mer from Alzheimer's disease amyloid Protein, ZINC ION | | 著者 | Zirah, S, Kozin, S.A, Mazur, A.K, Blond, A, Cheminant, M, Segalas-Milazzo, I, Debey, P, Rebuffat, S. | | 登録日 | 2005-04-18 | | 公開日 | 2005-05-03 | | 最終更新日 | 2013-10-09 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural changes of region 1-16 of the Alzheimer disease amyloid beta-peptide upon zinc binding and in vitro aging.
J.Biol.Chem., 281, 2006
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1Z0Q
 | | Aqueous Solution Structure of the Alzheimer's Disease Abeta Peptide (1-42) | | 分子名称: | Alzheimer's disease amyloid | | 著者 | Tomaselli, S, Esposito, V, Vangone, P, van Nuland, N.A, Bonvin, A.M, Guerrini, R, Tancredi, T, Temussi, P.A, Picone, D. | | 登録日 | 2005-03-02 | | 公開日 | 2006-05-23 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The alpha-to-beta Conformational Transition of Alzheimer's Abeta-(1-42) Peptide in Aqueous Media is Reversible: A Step by Step Conformational Analysis Suggests the Location of beta Conformation Seeding
Chembiochem, 7, 2006
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