1PCP
 
 | | SOLUTION STRUCTURE OF A TREFOIL-MOTIF-CONTAINING CELL GROWTH FACTOR, PORCINE SPASMOLYTIC PROTEIN | | Descriptor: | PORCINE SPASMOLYTIC PROTEIN | | Authors: | Carr, M.D, Bauer, C.J, Gradwell, M.J, Feeney, J. | | Deposit date: | 1993-02-04 | | Release date: | 1994-05-31 | | Last modified: | 2017-11-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of a trefoil-motif-containing cell growth factor, porcine spasmolytic protein.
Proc.Natl.Acad.Sci.USA, 91, 1994
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1A5J
 | | CHICKEN B-MYB DNA BINDING DOMAIN, REPEAT 2 AND REPEAT3, NMR, 32 STRUCTURES | | Descriptor: | B-MYB | | Authors: | Mcintosh, P.B, Carr, M.D, Wollborn, U, Frenkiel, T.A, Feeney, J, Mccormick, J.E, Klempnauer, K.H. | | Deposit date: | 1998-02-16 | | Release date: | 1998-07-01 | | Last modified: | 2022-02-16 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the B-Myb DNA-binding domain: a possible role for conformational instability of the protein in DNA binding and control of gene expression.
Biochemistry, 37, 1998
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5O57
 | | Solution Structure of the N-terminal Region of Dkk4 | | Descriptor: | Dickkopf-related protein 4 | | Authors: | Waters, L.C, Patel, S, Barkell, A.M, Muskett, F.W, Robinson, M.K, Holdsworth, G, Carr, M.D. | | Deposit date: | 2017-06-01 | | Release date: | 2018-06-13 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Structural and functional analysis of Dickkopf 4 (Dkk4): New insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins.
J. Biol. Chem., 293, 2018
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7OW1
 | | Crystal Structure of TAP01 in complex with amyloid beta peptide | | Descriptor: | Amyloid-beta precursor protein, CITRATE ANION, TAP01 family antibody heavy chain, ... | | Authors: | Hall, G, Cowan, R, Carr, M.D. | | Deposit date: | 2021-06-16 | | Release date: | 2022-06-29 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Discovery of a novel pseudo beta-hairpin structure of N-truncated amyloid-beta for use as a vaccine against Alzheimer's disease.
Mol Psychiatry, 27, 2022
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7OXN
 | | Crystal Structure of TAP01 in complex with cyclised amyloid beta peptide | | Descriptor: | 1,2-ETHANEDIOL, Amyloid-beta precursor protein, TAP01 family antibody heavy chain, ... | | Authors: | Hall, G, Cowan, R, Carr, M.D. | | Deposit date: | 2021-06-22 | | Release date: | 2022-06-29 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Discovery of a novel pseudo beta-hairpin structure of N-truncated amyloid-beta for use as a vaccine against Alzheimer's disease.
Mol Psychiatry, 27, 2022
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1NYO
 | | Solution structure of the antigenic TB protein MPT70/MPB70 | | Descriptor: | Immunogenic protein MPT70 | | Authors: | Bloemink, M.J, Dentten, E, Hewinson, R.G, Williamson, R.A, Carr, M.D, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2003-02-13 | | Release date: | 2003-08-19 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the Mycobacterium tuberculosis complex protein MPB70: from tuberculosis pathogenesis to inherited human corneal desease
J.Biol.Chem., 278, 2003
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2TMP
 | | N-TERMINAL DOMAIN OF TISSUE INHIBITOR OF METALLOPROTEINASE-2 (N-TIMP-2), NMR, 49 STRUCTURES | | Descriptor: | TISSUE INHIBITOR OF METALLOPROTEINASES-2 | | Authors: | Muskett, F.W, Frenkiel, T.A, Feeney, J, Freedman, R.B, Carr, M.D, Williamson, R.A. | | Deposit date: | 1998-05-26 | | Release date: | 1998-12-09 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | High resolution structure of the N-terminal domain of tissue inhibitor of metalloproteinases-2 and characterization of its interaction site with matrix metalloproteinase-3.
J.Biol.Chem., 273, 1998
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1WA8
 | | Solution Structure of the CFP-10.ESAT-6 Complex. Major Virulence Determinants of Pathogenic Mycobacteria | | Descriptor: | 6 KDA EARLY SECRETORY ANTIGENIC TARGET (ESAT-6), ESAT-6 LIKE PROTEIN ESXB | | Authors: | Renshaw, P.S, Lightbody, K.L, Veverka, V, Muskett, F.W, Kelly, G, Frenkiel, T.A, Gordon, S.V, Hewinson, R.G, Burke, B, Norman, J, Williamson, R.A, Carr, M.D, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2004-10-25 | | Release date: | 2005-06-27 | | Last modified: | 2019-08-21 | | Method: | SOLUTION NMR | | Cite: | Structure and Function of the Complex Formed by the Tuberculosis Virulence Factors Cfp-10 and Esat-6
Embo J., 24, 2005
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2HM8
 | | Solution Structure of the C-terminal MA-3 domain of Pdcd4 | | Descriptor: | Pdcd4 C-terminal MA-3 domain | | Authors: | Waters, L.C, Veverka, V, Bohm, M, Muskett, F.W, Choong, P.T, Klempnauer, K.H, Carr, M.D. | | Deposit date: | 2006-07-11 | | Release date: | 2007-02-20 | | Last modified: | 2022-03-09 | | Method: | SOLUTION NMR | | Cite: | Structure of the C-terminal MA-3 domain of the tumour suppressor protein Pdcd4 and characterization of its interaction with eIF4A
Oncogene, 26, 2007
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2KH2
 | | Solution structure of a scFv-IL-1B complex | | Descriptor: | Interleukin-1 beta, scFv | | Authors: | Wilkinson, I.C, Hall, C.J, Veverka, V, Muskett, F.W, Stephens, P.E, Taylor, R.J, Henry, A.J, Carr, M.D. | | Deposit date: | 2009-03-23 | | Release date: | 2009-09-08 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | High resolution NMR-based model for the structure of a scFv-IL-1beta complex: potential for NMR as a key tool in therapeutic antibody design and development.
J.Biol.Chem., 284, 2009
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2K8P
 | | Characterisation of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation | | Descriptor: | Sclerostin | | Authors: | Veverka, V, Henry, A.J, Slocombe, P.M, Ventom, A, Mulloy, B, Muskett, F.W, Muzylak, M, Greenslade, K, Moore, A, Zhang, L, Gong, J, Qian, X, Paszty, C, Taylor, R.J, Robinson, M.K, Carr, M.D. | | Deposit date: | 2008-09-18 | | Release date: | 2009-02-17 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | Characterization of the Structural Features and Interactions of Sclerostin: Molecular insight into a key regulator of Wnt-mediated bone formation
J.Biol.Chem., 284, 2009
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2L3Y
 | | Solution structure of mouse IL-6 | | Descriptor: | Interleukin-6 | | Authors: | Veverka, V, Redpath, N.T, Carrington, B, Muskett, F.W, Taylor, R.J, Henry, A.J, Carr, M.D. | | Deposit date: | 2010-09-25 | | Release date: | 2011-09-28 | | Last modified: | 2013-01-02 | | Method: | SOLUTION NMR | | Cite: | Conservation of functional sites on interleukin-6 and implications for evolution of signaling complex assembly and therapeutic intervention.
J.Biol.Chem., 287, 2012
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2KZT
 | | Structure of the Tandem MA-3 Region of Pdcd4 | | Descriptor: | Programmed cell death protein 4 | | Authors: | Waters, L.C, Strong, S.L, Oka, O, Muskett, F.W, Veverka, V, Banerjee, S, Schmedt, T, Henry, A.J, Klempnauer, K.H, Carr, M.D. | | Deposit date: | 2010-06-24 | | Release date: | 2011-03-16 | | Last modified: | 2011-11-23 | | Method: | SOLUTION NMR | | Cite: | Structure of the tandem MA-3 region of Pdcd4 protein and characterization of its interactions with eIF4A and eIF4G: molecular mechanisms of a tumor suppressor
J.Biol.Chem., 286, 2011
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2M4V
 | | Mycobacterium tuberculosis RNA polymerase binding protein A (RbpA) and its interactions with sigma factors | | Descriptor: | Putative uncharacterized protein | | Authors: | Bortoluzzi, A, Muskett, F.W, Waters, L.C, Addis, P.W, Rieck, B, Munder, T, Schleier, S, Forti, F, Ghisotti, D, Carr, M.D, O'Hare, H.M. | | Deposit date: | 2013-02-11 | | Release date: | 2013-04-17 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Mycobacterium tuberculosis RNA polymerase-binding protein A (RbpA) and its interactions with sigma factors.
J.Biol.Chem., 288, 2013
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2M2D
 | | Human programmed cell death 1 receptor | | Descriptor: | Programmed cell death protein 1 | | Authors: | Veverka, V, Cheng, X, Waters, L.C, Muskett, F.W, Morgan, S, Lesley, A, Griffiths, M, Stubberfield, C, Griffin, R, Henry, A.J, Robinson, M.K, Jansson, A, Ladbury, J.E, Ikemizu, S, Davis, S.J, Carr, M.D. | | Deposit date: | 2012-12-18 | | Release date: | 2013-02-27 | | Last modified: | 2013-05-15 | | Method: | SOLUTION NMR | | Cite: | Structure and interactions of the human programmed cell death 1 receptor.
J.Biol.Chem., 288, 2013
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2NPU
 | | The solution structure of the rapamycin-binding domain of mTOR (FRB) | | Descriptor: | FKBP12-rapamycin complex-associated protein | | Authors: | Veverka, V, Crabbe, T, Bird, I, Lennie, G, Muskett, F.W, Taylor, R.J, Carr, M.D. | | Deposit date: | 2006-10-30 | | Release date: | 2007-09-18 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR.
Oncogene, 27, 2008
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2C52
 | | Structural diversity in CBP p160 complexes | | Descriptor: | CREB-BINDING PROTEIN, NUCLEAR RECEPTOR COACTIVATOR 1 | | Authors: | Waters, L.C, Yue, B, Veverka, V, Renshaw, P.S, Bramham, J, Matsuda, S, Frenkiel, T, Kelly, G, Muskett, F.W, Carr, M.D, Heery, D.M. | | Deposit date: | 2005-10-25 | | Release date: | 2006-03-15 | | Last modified: | 2018-05-02 | | Method: | SOLUTION NMR | | Cite: | Structural diversity in p160/CREB-binding protein coactivator complexes.
J. Biol. Chem., 281, 2006
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2KG7
 | | Structure and features of the complex formed by the tuberculosis virulence factors Rv0287 and Rv0288 | | Descriptor: | ESAT-6-like protein esxH, Uncharacterized protein esxG (PE family protein) | | Authors: | Ilghari, D, Kirsty, L.L, Waters, L.C, Veverka, V.L, Philip, R.S, Carr, M.D. | | Deposit date: | 2009-03-06 | | Release date: | 2010-03-16 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the M. tuberculosis EsxG-EsxH complex: functional implications and comparisons with other M. tuberculosis Esx family complexes
J.Biol.Chem., 2011
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8APT
 | | Crystal Structure of H. influenzae TrmD in complex with Compound 13 | | Descriptor: | 6-[[3-(aminomethyl)phenyl]methylamino]pyridine-3-carboxamide, CITRIC ACID, tRNA (guanine-N(1)-)-methyltransferase | | Authors: | Hall, G, Cowan, R, Carr, M.D. | | Deposit date: | 2022-08-10 | | Release date: | 2023-06-14 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors.
Bioorg.Med.Chem.Lett., 90, 2023
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8APV
 | | Crystal Structure of H. influenzae TrmD in complex with Compound 27 | | Descriptor: | 1-[[4-(aminomethyl)phenyl]methyl]pyrrolo[2,3-b]pyridine-5-carboxamide, CITRIC ACID, tRNA (guanine-N(1)-)-methyltransferase | | Authors: | Hall, G, Cowan, R, Carr, M.D. | | Deposit date: | 2022-08-10 | | Release date: | 2023-06-14 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors.
Bioorg.Med.Chem.Lett., 90, 2023
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8APU
 | | Crystal Structure of H. influenzae TrmD in complex with Compound 14 | | Descriptor: | 6-[[4-(aminomethyl)phenyl]methylamino]pyridine-3-carboxamide, CITRIC ACID, tRNA (guanine-N(1)-)-methyltransferase | | Authors: | Hall, G, Cowan, R, Carr, M.D. | | Deposit date: | 2022-08-10 | | Release date: | 2023-06-14 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors.
Bioorg.Med.Chem.Lett., 90, 2023
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8APW
 | | Crystal Structure of H. influenzae TrmD in complex with Compound 30 | | Descriptor: | 1-[2-oxidanylidene-2-(piperidin-4-ylamino)ethyl]pyrrolo[2,3-b]pyridine-5-carboxamide, CITRIC ACID, tRNA (guanine-N(1)-)-methyltransferase | | Authors: | Hall, G, Cowan, R, Carr, M.D. | | Deposit date: | 2022-08-10 | | Release date: | 2023-06-14 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors.
Bioorg.Med.Chem.Lett., 90, 2023
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6I83
 | | Crystal structure of phosphorylated RET V804M tyrosine kinase domain complexed with PDD00018366 | | Descriptor: | 4-[5-(pyridin-3-ylmethylamino)pyrazolo[1,5-a]pyrimidin-3-yl]benzamide, FORMIC ACID, Proto-oncogene tyrosine-protein kinase receptor Ret | | Authors: | Burschowsky, D, Seewooruthun, C, Bayliss, R, Carr, M.D, Echalier, A, Jordan, A.M. | | Deposit date: | 2018-11-19 | | Release date: | 2020-03-11 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RETV804MKinase.
Acs Med.Chem.Lett., 11, 2020
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6I82
 | | Crystal structure of partially phosphorylated RET V804M tyrosine kinase domain complexed with PDD00018412 | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, FORMIC ACID, ... | | Authors: | Burschowsky, D, Seewooruthun, C, Bayliss, R, Carr, M.D, Echalier, A, Jordan, A.M. | | Deposit date: | 2018-11-19 | | Release date: | 2020-03-11 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RETV804MKinase.
Acs Med.Chem.Lett., 11, 2020
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