2K8P

Characterisation of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation

Summary for 2K8P

• Entry DOI: 10.2210/pdb2k8p/pdb
• Descriptor: Sclerostin (1 entity in total)
• Functional Keywords: wnt signalling pathway, bone formation, alternative splicing, glycoprotein, secreted, signaling protein
• Biological source: Homo sapiens (man)
• Cellular location: Secreted (Potential): Q9BQB4
• Total number of polymer chains: 1
• Total formula weight: 21432.33

Authors

Veverka, V.,Henry, A.J.,Slocombe, P.M.,Ventom, A.,Mulloy, B.,Muskett, F.W.,Muzylak, M.,Greenslade, K.,Moore, A.,Zhang, L.,Gong, J.,Qian, X.,Paszty, C.,Taylor, R.J.,Robinson, M.K.,Carr, M.D. (deposition date: 2008-09-18, release date: 2009-02-17, Last modification date: 2022-03-16)

• Primary citation: Veverka, V.,Henry, A.J.,Slocombe, P.M.,Ventom, A.,Mulloy, B.,Muskett, F.W.,Muzylak, M.,Greenslade, K.,Moore, A.,Zhang, L.,Gong, J.,Qian, X.,Paszty, C.,Taylor, R.J.,Robinson, M.K.,Carr, M.D.; Characterization of the Structural Features and Interactions of Sclerostin: Molecular insight into a key regulator of Wnt-mediated bone formation; J.Biol.Chem., 284:10890-10900, 2009; PubMed: 19208630; DOI: 10.1074/jbc.M807994200

Experimental method

SOLUTION NMR