2K8P

Characterisation of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001503	biological_process	ossification
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005794	cellular_component	Golgi apparatus
A	0008201	molecular_function	heparin binding
A	0009612	biological_process	response to mechanical stimulus
A	0016055	biological_process	Wnt signaling pathway
A	0030178	biological_process	negative regulation of Wnt signaling pathway
A	0030246	molecular_function	carbohydrate binding
A	0030279	biological_process	negative regulation of ossification
A	0030509	biological_process	BMP signaling pathway
A	0030514	biological_process	negative regulation of BMP signaling pathway
A	0031333	biological_process	negative regulation of protein-containing complex assembly
A	0032991	cellular_component	protein-containing complex
A	0036122	molecular_function	BMP binding
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0060070	biological_process	canonical Wnt signaling pathway
A	0071374	biological_process	cellular response to parathyroid hormone stimulus
A	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
A	0140297	molecular_function	DNA-binding transcription factor binding
A	0140678	molecular_function	molecular function inhibitor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	90
Details	Domain: {"description":"CTCK"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	65
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	11
Details	Compositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---