6I82

Crystal structure of partially phosphorylated RET V804M tyrosine kinase domain complexed with PDD00018412

Summary for 6I82

Entry DOI	10.2210/pdb6i82/pdb
Related	6I83
Descriptor	Proto-oncogene tyrosine-protein kinase receptor Ret, ~{N}-[3-(1,3-benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-~{N}',~{N}'-dimethyl-propane-1,3-diamine, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	inhibitor, kinase, proto-oncogene, oncoprotein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	73355.51
Authors	Burschowsky, D.,Seewooruthun, C.,Bayliss, R.,Carr, M.D.,Echalier, A.,Jordan, A.M. (deposition date: 2018-11-19, release date: 2020-03-11, Last modification date: 2024-01-24)
Primary citation	Newton, R.,Waszkowycz, B.,Seewooruthun, C.,Burschowsky, D.,Richards, M.,Hitchin, S.,Begum, H.,Watson, A.,French, E.,Hamilton, N.,Jones, S.,Lin, L.Y.,Waddell, I.,Echalier, A.,Bayliss, R.,Jordan, A.M.,Ogilvie, D. Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RETV804MKinase. Acs Med.Chem.Lett., 11:497-505, 2020 Cited by PubMed: 32292556 DOI: 10.1021/acsmedchemlett.9b00615 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation