6I82
Crystal structure of partially phosphorylated RET V804M tyrosine kinase domain complexed with PDD00018412
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Proto-oncogene tyrosine-protein kinase receptor Ret | polymer | 314 | 35820.3 | 2 | UniProt (P07949) Pfam (PF07714) | Homo sapiens (Human) | Cadherin family member 12,Proto-oncogene c-Ret |
| 2 | C, O (A, B) | ~{N}-[3-(1,3-benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-~{N}',~{N}'-dimethyl-propane-1,3-diamine | non-polymer | 339.4 | 2 | Chemie (H6W) | |||
| 3 | D, E, P, Q, R (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 4 | F, G, H, I, J... (A, B) | FORMIC ACID | non-polymer | 46.0 | 15 | Chemie (FMT) | |||
| 5 | N (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | AA, Z (B, A) | water | water | 18.0 | 212 | Chemie (HOH) |
Sequence modifications
A, B: 705 - 1013 (UniProt: P07949)
| PDB | External Database | Details |
|---|---|---|
| Gly 700 | - | expression tag |
| Pro 701 | - | expression tag |
| Leu 702 | - | expression tag |
| Ser 703 | - | expression tag |
| Leu 704 | - | expression tag |
| Met 804 | Val 804 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71640.6 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 1715.0 | |
| All* | Total formula weight | 73355.5 |
