8APW

Crystal Structure of H. influenzae TrmD in complex with Compound 30

Summary for 8APW

Entry DOI	10.2210/pdb8apw/pdb
Descriptor	tRNA (guanine-N(1)-)-methyltransferase, CITRIC ACID, 1-[2-oxidanylidene-2-(piperidin-4-ylamino)ethyl]pyrrolo[2,3-b]pyridine-5-carboxamide, ... (4 entities in total)
Functional Keywords	methyltransferase, rna binding protein
Biological source	Haemophilus influenzae
Total number of polymer chains	1
Total formula weight	30243.48
Authors	Hall, G.,Cowan, R.,Carr, M.D. (deposition date: 2022-08-10, release date: 2023-06-14, Last modification date: 2024-02-07)
Primary citation	Wilkinson, A.J.,Ooi, N.,Finlayson, J.,Lee, V.E.,Lyth, D.,Maskew, K.S.,Newman, R.,Orr, D.,Ansell, K.,Birchall, K.,Canning, P.,Coombs, P.,Fusani, L.,McIver, E.,Pisco, J.,Ireland, P.M.,Jenkins, C.,Norville, I.H.,Southern, S.J.,Cowan, R.,Hall, G.,Kettleborough, C.,Savage, V.J.,Cooper, I.R. Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors. Bioorg.Med.Chem.Lett., 90:129331-129331, 2023 Cited by PubMed: 37187252 DOI: 10.1016/j.bmcl.2023.129331 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation