5O57

Solution Structure of the N-terminal Region of Dkk4

Summary for 5O57

DescriptorDickkopf-related protein 4 (1 entity in total)
Functional Keywordsdkk4, wnt signalling, cysteine-rich domain 1, signaling protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight10931.43
Authors
Waters, L.C.,Patel, S.,Barkell, A.M.,Muskett, F.W.,Robinson, M.K.,Holdsworth, G.,Carr, M.D. (deposition date: 2017-06-01, release date: 2018-06-13, Last modification date: 2018-08-15)
Primary citation
Patel, S.,Barkell, A.M.,Gupta, D.,Strong, S.L.,Bruton, S.,Muskett, F.W.,Addis, P.W.,Renshaw, P.S.,Slocombe, P.M.,Doyle, C.,Clargo, A.,Taylor, R.J.,Prosser, C.E.,Henry, A.J.,Robinson, M.K.,Waters, L.C.,Holdsworth, G.,Carr, M.D.
Structural and functional analysis of Dickkopf 4 (Dkk4): New insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins.
J. Biol. Chem., 293:12149-12166, 2018
PubMed: 29925589 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.RA118.002918
MImport into Mendeley
Experimental method
SOLUTION NMR
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Structure validation

ClashscoreRamachandran outliersSidechain outliers20.8%31.1%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures

More Asymmetric unit images

Molmil generated image of 5o57
no rotation
Molmil generated image of 5o57
rotated about x axis by 90°
Molmil generated image of 5o57
rotated about y axis by 90°
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