3DXC

Crystal structure of the intracellular domain of human APP in complex with Fe65-PTB2

Summary for 3DXC

Entry DOI	10.2210/pdb3dxc/pdb
Related	3DXD 3DXE
Descriptor	Amyloid beta A4 protein-binding family B member 1, Amyloid beta A4 protein (3 entities in total)
Functional Keywords	alzheimer's disease, app, aicd, fe65, ptb domain, alzheimer disease, amyloid, apoptosis, cell adhesion, coated pit, disease mutation, endocytosis, glycoprotein, heparin-binding, iron, membrane, metal-binding, notch signaling pathway, phosphoprotein, protease inhibitor, proteoglycan, serine protease inhibitor, transmembrane, protein binding
Biological source	Homo sapiens (Human) More
Cellular location	Cell membrane: O00213 Membrane; Single-pass type I membrane protein: P05067
Total number of polymer chains	4
Total formula weight	39110.39
Authors	Radzimanowski, J.,Sinning, I.,Wild, K. (deposition date: 2008-07-24, release date: 2008-09-16, Last modification date: 2024-02-21)
Primary citation	Radzimanowski, J.,Simon, B.,Sattler, M.,Beyreuther, K.,Sinning, I.,Wild, K. Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2. Embo Rep., 9:1134-1140, 2008 Cited by PubMed: 18833287 DOI: 10.1038/embor.2008.188 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation