3DXC

Crystal structure of the intracellular domain of human APP in complex with Fe65-PTB2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001540	molecular_function	amyloid-beta binding
B	0016020	cellular_component	membrane
C	0001540	molecular_function	amyloid-beta binding
D	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00320
Number of Residues	8
Details	APP_INTRA Amyloid precursor protein (APP) intracellular domain signature. GYENPTYK

Chain	Residue	Details
B	GLY681-LYS688

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by ABL1","evidences":[{"source":"PubMed","id":"15031292","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18922798","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by SGK1","evidences":[{"source":"UniProtKB","id":"P46933","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	10
Details	Motif: {"description":"YENPXY motif; contains endocytosis signal","evidences":[{"source":"PubMed","id":"10383380","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by CDK5 and MAPK10","evidences":[{"source":"PubMed","id":"28720718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8131745","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"11877420","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P08592","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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