5AM8

Crystal structure of the Angiotensin-1 converting enzyme N-domain in complex with amyloid-beta 4-10

Summary for 5AM8

Entry DOI	10.2210/pdb5am8/pdb
Related	4UFA 4UFB 5AM9 5AMA 5AMB 5AMC
Descriptor	ANGIOTENSIN-CONVERTING ENZYME, SULFATE ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (14 entities in total)
Functional Keywords	hydrolase, metalloprotease, amyloid-beta
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	8
Total formula weight	302594.28
Authors	Masuyer, G.,Larmuth, K.M.,Douglas, R.G.,Sturrock, E.D.,Acharya, K.R. (deposition date: 2015-03-10, release date: 2016-01-13, Last modification date: 2024-01-10)
Primary citation	Larmuth, K.M.,Masuyer, G.,Douglas, R.G.,Sturrock, E.D.,Acharya, K.R. The Kinetic and Structural Characterisation of Amyloid-Beta Metabolism by Human Angiotensin-1- Converting Enzyme (Ace) FEBS J., 283:1060-, 2016 Cited by PubMed: 26748546 DOI: 10.1111/FEBS.13647 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation