3V19
 
 | | Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health | | 分子名称: | CHLORIDE ION, Insulin, PHENOL, ... | | 著者 | Wan, Z.L, Hua, Q.X, Wickramasinghe, N.P, Huang, K, Petkova, A.T, Hu, S.Q, Phillips, N.B, Yeh, I.J, Whittake, J, Ismail-Beigi, F, Katsoyyannis, P.G, Tycko, R, Weiss, M.A. | | 登録日 | 2011-12-09 | | 公開日 | 2012-12-12 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Forestalling insulin fibrillation by insertion of a
chiral clamp mechanism-based application of protein engineering to global health
To be Published
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2R36
 | | Crystal structure of ni human ARG-insulin | | 分子名称: | CHLORIDE ION, Insulin, NICKEL (II) ION, ... | | 著者 | Sreekanth, R, Pattabhi, V, Rajan, S.S. | | 登録日 | 2007-08-29 | | 公開日 | 2008-09-02 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Metal induced structural changes observed in hexameric insulin
Int.J.Biol.Macromol., 44, 2009
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1J73
 | | Crystal structure of an unstable insulin analog with native activity. | | 分子名称: | ZINC ION, insulin a, insulin b | | 著者 | Wan, Z, Zhao, M, Nakagawa, S, Jia, W, Weiss, M.A. | | 登録日 | 2001-05-15 | | 公開日 | 2001-05-30 | | 最終更新日 | 2021-10-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.
J.Mol.Biol., 315, 2002
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2W44
 | | Structure DeltaA1-A4 insulin | | 分子名称: | CHLORIDE ION, INSULIN, RESORCINOL, ... | | 著者 | Thorsoee, K.S, Schlein, M, Brandt, J, Schluckebier, G, Naver, H. | | 登録日 | 2008-11-21 | | 公開日 | 2009-12-22 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Kinetic Evidence for the Sequential Association of Insulin Binding Sites 1 and 2 to the Insulin Receptor and the Influence of Receptor Isoform.
Biochemistry, 49, 2010
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1Q4V
 | | CRYSTAL STRUCTURE OF ALLO-ILEA2-INSULIN, AN INACTIVE CHIRAL ANALOGUE: IMPLICATIONS FOR THE MECHANISM OF RECEPTOR | | 分子名称: | Insulin, PHENOL, ZINC ION | | 著者 | Wan, Z.L, Xu, B, Chu, Y.C, Katsoyannis, P.G, Weiss, M.A. | | 登録日 | 2003-08-04 | | 公開日 | 2003-08-19 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of allo-Ile(A2)-insulin, an inactive chiral analogue: implications for the
mechanism of receptor binding.
Biochemistry, 42, 2003
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2OMQ
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1ZNJ
 | | INSULIN, MONOCLINIC CRYSTAL FORM | | 分子名称: | CHLORIDE ION, INSULIN, PHENOL, ... | | 著者 | Turkenburg, M.G.W, Whittingham, J.L, Turkenburg, J.P, Dodson, G.G, Derewenda, U, Smith, G.D, Dodson, E.J, Derewenda, Z.S, Xiao, B. | | 登録日 | 1997-09-23 | | 公開日 | 1998-01-28 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure Determination and Refinement of Two Crystal Forms of Native Insulins
To be Published
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1QIZ
 | | HUMAN INSULIN HEXAMERS WITH CHAIN B HIS MUTATED TO TYR COMPLEXED WITH RESORCINOL | | 分子名称: | CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ... | | 著者 | Tang, L, Whittingham, J.L, Verma, C.S, Caves, L.S.D, Dodson, G.G. | | 登録日 | 1999-06-18 | | 公開日 | 1999-06-22 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural Consequences of the B5 Histidine --> Tyrosine Mutation in Human Insulin Characterized by X-Ray Crystallography and Conformational Analysis.
Biochemistry, 38, 1999
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3P2X
 | | Insulin fibrillation is the Janus face of induced fit. A chiaral clamp stabilizes the native state at the expense of activity | | 分子名称: | CHLORIDE ION, Insulin, PHENOL, ... | | 著者 | Hua, Q.X, Wan, Z.L, Huang, K, Hu, S.Q, Phillip, N.F, Jia, W.H, Whittingham, J, Dodson, G.G, Katsoyannis, P.G, Weiss, M.A. | | 登録日 | 2010-10-04 | | 公開日 | 2011-11-23 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
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2QIU
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4FG3
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4AKJ
 | | Ligand controlled assembly of hexamers, dihexamers, and linear multihexamer structures by an engineered acylated insulin | | 分子名称: | CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ... | | 著者 | Steensgaard, D.B, Schluckebier, G, Strauss, H.M, Norrman, M, Thomsen, J.K, Friderichsen, A.V, Havelund, S, Jonassen, I. | | 登録日 | 2012-02-23 | | 公開日 | 2013-01-09 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Ligand Controlled Assembly of Hexamers, Dihexamers, and Linear Multihexamer Structures by the Engineered Acylated Insulin Degludec.
Biochemistry, 52, 2013
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5MT3
 | | Human insulin in complex with serotonin and arginine | | 分子名称: | ARGININE, CHLORIDE ION, Insulin, ... | | 著者 | Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. | | 登録日 | 2017-01-06 | | 公開日 | 2017-04-05 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules.
J. Biol. Chem., 292, 2017
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3Q6E
 | | Human insulin in complex with cucurbit[7]uril | | 分子名称: | Insulin A chain, Insulin B chain, cucurbit[7]uril | | 著者 | Chinai, J.M, Taylor, A.B, Hargreaves, N.D, Ryno, L.M, Morris, C.A, Hart, P.J, Urbach, A.R. | | 登録日 | 2010-12-31 | | 公開日 | 2011-04-20 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Molecular recognition of insulin by a synthetic receptor.
J.Am.Chem.Soc., 133, 2011
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8GSG
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2OM0
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5USS
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1W8P
 | | Structural properties of the B25Tyr-NMe-B26Phe insulin mutant. | | 分子名称: | INSULIN A-CHAIN, INSULIN B-CHAIN, PHENOL, ... | | 著者 | Zakowa, L, Au-Alvarez, O, Dodson, E.J, Dodson, G.G, Brzozowski, A.M. | | 登録日 | 2004-09-24 | | 公開日 | 2005-02-03 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | Towards the Insulin-Igf-I Intermediate Structures: Functional and Structural Properties of the B25Tyr-Nme-B26Phe Insulin Mutant.
Biochemistry, 43, 2004
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2R35
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2WS0
 | | Semi-synthetic analogue of human insulin NMeAlaB26-insulin at pH 7.5 | | 分子名称: | INSULIN A CHAIN, INSULIN B CHAIN | | 著者 | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | | 登録日 | 2009-09-03 | | 公開日 | 2010-02-09 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
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8PI6
 | | Crystal structure of the monomeric zinc free human insulin A22K, B3E, B26E, B29R, desB30 precursor with a Ser-Glu-Asp-Trp-Trp-Arg C-peptide and a Glu-Glu-Gly-Glu-Pro-Arg N-terminal extension | | 分子名称: | Insulin B chain,Insulin A chain | | 著者 | Johansson, E, Schluckebier, G. | | 登録日 | 2023-06-21 | | 公開日 | 2023-11-08 | | 最終更新日 | 2024-04-17 | | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | | 主引用文献 | Molecular engineering of insulin for recombinant expression in yeast.
Trends Biotechnol, 42, 2024
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8PJC
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2WRV
 | | Semi-synthetic highly active analogue of human insulin NMeHisB26-DTI- NH2 | | 分子名称: | ACETATE ION, INSULIN A CHAIN, INSULIN B CHAIN | | 著者 | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | | 登録日 | 2009-09-02 | | 公開日 | 2010-02-09 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
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5HPU
 | | Insulin with proline analog HyP at position B28 in the R6 state | | 分子名称: | CHLORIDE ION, Insulin, chain A, ... | | 著者 | Lieblich, S.A, Fang, K.Y, Cahn, J.K.B, Tirrell, D.A. | | 登録日 | 2016-01-21 | | 公開日 | 2017-01-25 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | 4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation.
J. Am. Chem. Soc., 139, 2017
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2G56
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