5MT3

Human insulin in complex with serotonin and arginine

Summary for 5MT3

DescriptorInsulin, ZINC ION, CHLORIDE ION, ... (7 entities in total)
Functional Keywordshormone, serotonin, arginine, complex, specificity
Biological sourceHomo sapiens (Human)
Cellular locationSecreted P01308 P01308
Total number of polymer chains32
Total molecular weight96633.82
Authors
Brzozowski, A.M.,Turkenburg, J.P.,Jiracek, J.,Zakova, L. (deposition date: 2017-01-06, release date: 2017-04-05, Last modification date: 2017-05-31)
Primary citation
Palivec, V.,Viola, C.M.,Kozak, M.,Ganderton, T.R.,Krizkova, K.,Turkenburg, J.P.,Haluskova, P.,Zakova, L.,Jiracek, J.,Jungwirth, P.,Brzozowski, A.M.
Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules.
J. Biol. Chem., 292:8342-8355, 2017
PubMed: 28348075 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M117.775924
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.02 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.31260.4%4.8%2.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution