1W8P

Structural properties of the B25Tyr-NMe-B26Phe insulin mutant.

Summary for 1W8P

Related1A7F 1AI0 1AIY 1B9E 1BEN 1EFE 1EV3 1EV6 1EVR 1FU2 1FUB 1G7A 1G7B 1GUJ 1HIQ 1HIS 1HIT 1HLS 1HTV 1HUI 1IOG 1IOH 1J73 1JCA 1JCO 1K3M 1KMF 1LKQ 1LNP 1LPH 1MHI 1MHJ 1MSO 1OS3 1OS4 1Q4V 1QIY 1QIZ 1QJ0 1SF1 1SJT 1SJU 1T1K 1T1P 1T1Q 1TRZ 1TYL 1TYM 1UZ9 1VKT 1XDA 1XGL 1ZEG 1ZEH 1ZNJ 2AIY 2HIU 3AIY 4AIY 5AIY
DescriptorINSULIN A-CHAIN, INSULIN B-CHAIN, PHENOL, ... (5 entities in total)
Functional Keywordsinsulin, igf-1, mutants, hormone/growth factor, hormone-growth factor complex
Biological sourceHOMO SAPIENS
Cellular locationSecreted P01308 P01308
Total number of polymer chains12
Total molecular weight35601.39
Authors
Zakowa, L.,Au-Alvarez, O.,Dodson, E.J.,Dodson, G.G.,Brzozowski, A.M. (deposition date: 2004-09-24, release date: 2005-02-03, Last modification date: 2017-06-28)
Primary citation
Zarkowa, L.,Brynda, J.,Au-Alvarez, O.,Dodson, E.J.,Dodson, G.G.,Whittingham, J.L.,Brzozowski, A.M.
Towards the Insulin-Igf-I Intermediate Structures: Functional and Structural Properties of the B25Tyr-Nme-B26Phe Insulin Mutant.
Biochemistry, 43:16293-, 2004
PubMed: 15610023 (PDB entries with the same primary citation)
DOI: 10.1021/BI048856U
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.08 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers140.4%6.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1w8p
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Molmil generated image of 1w8p
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Molmil generated image of 1w8p
rotated about y axis by 90°