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PDB: 354 件
2M2P
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BU of 2m2p by Molmil
Structure of [D-HisB24] insulin analogue at pH 8.0
分子名称: Insulin A chain, Insulin B chain
著者Zakova, L, Veverka, V, Jiracek, J.
登録日2012-12-29
公開日2013-03-06
最終更新日2013-06-05
実験手法SOLUTION NMR
主引用文献Structural integrity of the B24 site in human insulin is important for hormone functionality.
J.Biol.Chem., 288, 2013
2M2M
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BU of 2m2m by Molmil
Structure of [L-HisB24] insulin analogue at pH 1.9
分子名称: Insulin A chain, Insulin B chain
著者Zakova, L, Veverka, V, Jiracek, J.
登録日2012-12-28
公開日2013-03-06
最終更新日2013-06-05
実験手法SOLUTION NMR
主引用文献Structural integrity of the B24 site in human insulin is important for hormone functionality.
J.Biol.Chem., 288, 2013
2M1E
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BU of 2m1e by Molmil
Biosynthetic engineered B28K-B29P human insulin monomer structure in in water solutions.
分子名称: Insulin
著者Bocian, W, Kozerski, L.
登録日2012-11-26
公開日2013-02-27
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Biosynthetic engineered B28(K)-B29(P) human insulin monomer structure in water and in water/acetonitrile solutions.
J.Biomol.Nmr, 55, 2013
1K3M
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BU of 1k3m by Molmil
NMR STRUCTURE OF HUMAN INSULIN MUTANT ILE-A2-ALA, HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES
分子名称: INSULIN
著者Xu, B, Hua, Q.-X, Nakagawa, S.H, Jia, W, Chu, Y.-C, Katsoyannis, P.G, Weiss, M.A.
登録日2001-10-03
公開日2001-10-17
最終更新日2021-10-27
実験手法SOLUTION NMR
主引用文献A cavity-forming mutation in insulin induces segmental unfolding of a surrounding alpha-helix.
Protein Sci., 11, 2002
1HIS
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BU of 1his by Molmil
Structure and dynamics of des-pentapeptide-insulin in solution: the molten-globule hypothesis.
分子名称: INSULIN
著者Hua, Q.X, Kochoyan, M, Weiss, M.A.
登録日1992-02-28
公開日1994-01-31
最終更新日2022-02-23
実験手法SOLUTION NMR
主引用文献Structure and dynamics of des-pentapeptide-insulin in solution: the molten-globule hypothesis.
Proc.Natl.Acad.Sci.USA, 89, 1992
1JCO
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BU of 1jco by Molmil
Solution structure of the monomeric [Thr(B27)->Pro,Pro(B28)->Thr] insulin mutant (PT insulin)
分子名称: Insulin A chain, Insulin B chain
著者Keller, D, Clausen, R, Josefsen, K, Led, J.J.
登録日2001-06-11
公開日2001-10-03
最終更新日2021-10-27
実験手法SOLUTION NMR
主引用文献Flexibility and bioactivity of insulin: an NMR investigation of the solution structure and folding of an unusually flexible human insulin mutant with increased biological activity.
Biochemistry, 40, 2001
2N2X
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BU of 2n2x by Molmil
Solution structure of [GlyB24,B27-B29 triazole cross-linked]-insulin analogue at pH 1.9
分子名称: Insulin A chain, Insulin B chain
著者Veverka, V, Hexnerova, R, Jiracek, J.
登録日2015-05-15
公開日2016-02-03
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献Rational steering of insulin binding specificity by intra-chain chemical crosslinking.
Sci Rep, 6, 2016
2N2W
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BU of 2n2w by Molmil
Solution structure of [B26-B29 triazole cross-linked]-insulin analogue at pH 8.0
分子名称: Insulin A chain, Insulin B chain
著者Veverka, V, Hexnerova, R, Jiracek, J.
登録日2015-05-15
公開日2016-02-03
実験手法SOLUTION NMR
主引用文献Rational steering of insulin binding specificity by intra-chain chemical crosslinking.
Sci Rep, 6, 2016
2MPI
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BU of 2mpi by Molmil
Solution structure of B24G insulin
分子名称: insulin chain A, insulin chain B
著者Yang, Y, Wickramasinghe, N.P, Hua, Q, Weiss, M.A.
登録日2014-05-19
公開日2014-12-24
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
2MPG
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BU of 2mpg by Molmil
Solution structure of the [AibB8,LysB28,ProB29]-insulin analogue
分子名称: Insulin A chain, Insulin B chain
著者Kosinova, L, Jiracek, J, Zakova, L, Veverka, V.
登録日2014-05-17
公開日2014-06-11
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献Insight into the structural and biological relevance of the T/R transition of the N-terminus of the B-chain in human insulin.
Biochemistry, 53, 2014
5MHD
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BU of 5mhd by Molmil
Biosynthetic engineered A22S-B3K-B31R human insulin monomer structure in water/acetonitrile solutions.
分子名称: Insulin
著者Bocian, W, Kozerski, L, Bednarek, E, Sitkowski, J.
登録日2016-11-24
公開日2017-08-09
最終更新日2019-05-08
実験手法SOLUTION NMR
主引用文献Structure and pharmaceutical formulation development of a new long-acting recombinant human insulin analog studied by NMR and MS.
J Pharm Biomed Anal, 135, 2017
2N2V
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BU of 2n2v by Molmil
Solution structure of [B26-B29 triazole cross-linked]-insulin analogue at pH 1.9
分子名称: Insulin A chain, Insulin B chain
著者Veverka, V, Hexnerova, R, Jiracek, J.
登録日2015-05-15
公開日2016-02-03
実験手法SOLUTION NMR
主引用文献Rational steering of insulin binding specificity by intra-chain chemical crosslinking.
Sci Rep, 6, 2016
1HIQ
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BU of 1hiq by Molmil
PARADOXICAL STRUCTURE AND FUNCTION IN A MUTANT HUMAN INSULIN ASSOCIATED WITH DIABETES MELLITUS
分子名称: INSULIN
著者Hua, Q.X, Shoelson, S.E, Inouye, K, Weiss, M.A.
登録日1993-03-05
公開日1994-01-31
最終更新日2017-11-29
実験手法SOLUTION NMR
主引用文献Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus.
Proc.Natl.Acad.Sci.USA, 90, 1993
5MWQ
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BU of 5mwq by Molmil
Biosynthetic engineered A21K-B31K-B32R human insulin monomer structure in water/acetonitrile solution
分子名称: Insulin
著者Bocian, W, Kozerski, L.
登録日2017-01-19
公開日2018-02-14
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Lysine mis-incorporation at asparagine position during recombinant proteins production in E. coli
To Be Published
5AIY
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BU of 5aiy by Molmil
R6 HUMAN INSULIN HEXAMER (SYMMETRIC), NMR, 'RED' SUBSTATE, AVERAGE STRUCTURE
分子名称: PHENOL, PROTEIN (INSULIN)
著者O'Donoghue, S.I, Chang, X, Abseher, R, Nilges, M, Led, J.J.
登録日1998-12-29
公開日2000-02-28
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献Unraveling the symmetry ambiguity in a hexamer: calculation of the R6 human insulin structure.
J.Biomol.NMR, 16, 2000
2KJJ
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BU of 2kjj by Molmil
Dynamics of insulin probed by 1H-NMR amide proton exchange anomalous flexibility of the receptor-binding surface
分子名称: Insulin
著者Hua, Q.X, Weiss, M.A.
登録日2009-05-29
公開日2010-06-16
最終更新日2021-10-13
実験手法SOLUTION NMR
主引用文献Dynamics of Insulin Probed by 1H-NMR Amide Proton E Anomalous Flexibility of the Receptor-Binding Surfa
To be Published
6U46
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BU of 6u46 by Molmil
Solution Structure of a Heat-Resistant Long-Acting Insulin Analog
分子名称: Insulin
著者Yang, Y, Weiss, M.A.
登録日2019-08-23
公開日2020-08-26
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Solution Structure of a Heat-Resistant Long-Acting Insulin Analog
To Be Published
1SF1
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BU of 1sf1 by Molmil
NMR STRUCTURE OF HUMAN INSULIN under Amyloidogenic Condition, 15 STRUCTURES
分子名称: INSULIN A CHAIN, Insulin
著者Weiss, M.A, Hua, Q.X.
登録日2004-02-19
公開日2004-03-30
最終更新日2022-03-02
実験手法SOLUTION NMR
主引用文献Mechanism of insulin fibrillation: the structure of insulin under amyloidogenic conditions resembles a protein-folding intermediate
J.Biol.Chem., 279, 2004
5WBT
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BU of 5wbt by Molmil
Solution Structure and Dynamics of an Ultra-Stable Single-Chain Insulin Analog STUDIES OF AN ENGINEERED MONOMER AND IMPLICATIONS FOR RECEPTOR BINDING
分子名称: Insulin
著者Glidden, M.D, Yang, Y, Wickramasinghe, N.P, Weiss, M.A.
登録日2017-06-29
公開日2017-11-15
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding.
J. Biol. Chem., 293, 2018
2H67
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BU of 2h67 by Molmil
NMR structure of human insulin mutant HIS-B5-ALA, HIS-B10-ASP PRO-B28-LYS, LYS-B29-PRO, 20 structures
分子名称: Insulin A chain, Insulin B chain
著者Hua, Q.X, Liu, M, Hu, S.Q, Jia, W, Arvan, P, Weiss, M.A.
登録日2006-05-30
公開日2006-07-18
最終更新日2021-10-20
実験手法SOLUTION NMR
主引用文献A Conserved Histidine in Insulin Is Required for the Foldability of Human Proinsulin: Structure and function of an Alab5 analog.
J.Biol.Chem., 281, 2006
1AIY
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BU of 1aiy by Molmil
R6 HUMAN INSULIN HEXAMER (SYMMETRIC), NMR, 10 STRUCTURES
分子名称: PHENOL, R6 INSULIN HEXAMER, ZINC ION
著者Chang, X, Jorgensen, A.M.M, Bardrum, P, Led, J.J.
登録日1997-04-30
公開日1997-11-12
最終更新日2022-02-16
実験手法SOLUTION NMR
主引用文献Solution structures of the R6 human insulin hexamer.
Biochemistry, 36, 1997
2K9R
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BU of 2k9r by Molmil
Enhancing the activity of insulin by stereospecific unfolding
分子名称: Insulin
著者Hua, Q.X, Xu, B, Huang, K, Hu, S.Q, Nakarawa, S, Jia, W.H, Philips, N.F.P, Wittaker, L, Wittaker, J, Katsoyannis, P.G, Weiss, M.A.
登録日2008-10-23
公開日2008-11-11
最終更新日2021-10-20
実験手法SOLUTION NMR
主引用文献Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS.
J.Biol.Chem., 284, 2009
2K91
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BU of 2k91 by Molmil
Enhancing the activity of insulin by stereospecific unfolding
分子名称: Insulin
著者Hua, Q.X, Xu, B, Huang, K, Hu, S.Q, Nakarawa, S, Jia, W.H, Philips, N.F.P, Wittaker, L, Wittaker, J, Katsoyannis, P.G, Weiss, M.A.
登録日2008-09-29
公開日2008-11-18
最終更新日2021-10-20
実験手法SOLUTION NMR
主引用文献Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS.
J.Biol.Chem., 284, 2009
4AIY
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BU of 4aiy by Molmil
R6 HUMAN INSULIN HEXAMER (SYMMETRIC), NMR, 'GREEN' SUBSTATE, AVERAGE STRUCTURE
分子名称: PHENOL, PROTEIN (INSULIN)
著者O'Donoghue, S.I, Chang, X, Abseher, R, Nilges, M, Led, J.J.
登録日1998-12-29
公開日2000-02-28
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献Unraveling the symmetry ambiguity in a hexamer: calculation of the R6 human insulin structure.
J.Biomol.NMR, 16, 2000
1KMF
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BU of 1kmf by Molmil
NMR STRUCTURE OF HUMAN INSULIN MUTANT ILE-A2-ALLO-ILE, HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES
分子名称: Insulin
著者Xu, B, Hua, Q.X, Nakagawa, S.H, Jia, W, Chu, Y.C, Katsoyannis, P.G, Weiss, M.A.
登録日2001-12-14
公開日2002-01-09
最終更新日2021-10-27
実験手法SOLUTION NMR
主引用文献Chiral mutagenesis of insulin's hidden receptor-binding surface: structure of an allo-isoleucine(A2) analogue.
J.Mol.Biol., 316, 2002

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