1K3M

NMR STRUCTURE OF HUMAN INSULIN MUTANT ILE-A2-ALA, HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES

Summary for 1K3M

DescriptorINSULIN (2 entities in total)
Functional Keywordshormone, human insulin, mutant, hormone-growth factor complex, hormone/growth factor
Cellular locationSecreted P01308 P01308
Total number of polymer chains2
Total molecular weight5752.51
Authors
Xu, B.,Hua, Q.-X.,Nakagawa, S.H.,Jia, W.,Chu, Y.-C.,Katsoyannis, P.G.,Weiss, M.A. (deposition date: 2001-10-03, release date: 2001-10-17, Last modification date: 2011-07-13)
Primary citation
Xu, B.,Hua, Q.X.,Nakagawa, S.H.,Jia, W.,Chu, Y.C.,Katsoyannis, P.G.,Weiss, M.A.
A cavity-forming mutation in insulin induces segmental unfolding of a surrounding alpha-helix.
Protein Sci., 11:104-116, 2002
PubMed: 11742127 (PDB entries with the same primary citation)
DOI: 10.1110/ps.ps.32102
MImport into Mendeley
Experimental method
SOLUTION NMR
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers6912.8%35.2%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures