5WBT

Solution Structure and Dynamics of an Ultra-Stable Single-Chain Insulin Analog STUDIES OF AN ENGINEERED MONOMER AND IMPLICATIONS FOR RECEPTOR BINDING

Summary for 5WBT

• Entry DOI: 10.2210/pdb5wbt/pdb
• NMR Information: BMRB: 30314
• Descriptor: Insulin (1 entity in total)
• Functional Keywords: heat-stable, hormone
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 6515.31

Authors

Glidden, M.D.,Yang, Y.,Wickramasinghe, N.P.,Weiss, M.A. (deposition date: 2017-06-29, release date: 2017-11-15, Last modification date: 2023-06-14)

• Primary citation: Glidden, M.D.,Yang, Y.,Smith, N.A.,Phillips, N.B.,Carr, K.,Wickramasinghe, N.P.,Ismail-Beigi, F.,Lawrence, M.C.,Smith, B.J.,Weiss, M.A.; Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding.; J. Biol. Chem., 293:69-88, 2018; PubMed: 29114034; DOI: 10.1074/jbc.M117.808667

Experimental method

SOLUTION NMR