2RF9
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![BU of 2rf9 by Molmil](/molmil-images/mine/2rf9) | Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide | 分子名称: | ERBB receptor feedback inhibitor 1, Epidermal growth factor receptor | 著者 | Zhang, X, Pickin, K.A, Bose, R, Jura, N, Cole, P.A, Kuriyan, J. | 登録日 | 2007-09-28 | 公開日 | 2007-12-04 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature, 450, 2007
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2JIV
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![BU of 2jiv by Molmil](/molmil-images/mine/2jiv) | Crystal structure of EGFR kinase domain T790M mutation in compex with HKI-272 | 分子名称: | CHLORIDE ION, EPIDERMAL GROWTH FACTOR RECEPTOR, N-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | 著者 | Yun, C.-H, Mengwasser, K.E, Toms, A.V, Li, Y, Woo, M.S, Greulich, H, Wong, K.-K, Meyerson, M, Eck, M.J. | 登録日 | 2007-07-02 | 公開日 | 2008-01-22 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | The T790M Mutation in Egfr Kinase Causes Drug Resistance by Increasing the Affinity for ATP. Proc.Natl.Acad.Sci.USA, 105, 2008
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7LFS
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![BU of 7lfs by Molmil](/molmil-images/mine/7lfs) | Crystal structure of the epidermal growth factor receptor extracellular region with A265V mutation in complex with epiregulin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 4 of Epidermal growth factor receptor, ... | 著者 | Hu, C, Leche II, C.A, Stayrook, S.E, Ferguson, K.M, Lemmon, M.A. | 登録日 | 2021-01-18 | 公開日 | 2021-11-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias. Nature, 602, 2022
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4LRM
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![BU of 4lrm by Molmil](/molmil-images/mine/4lrm) | EGFR D770_N771insNPG in complex with PD168393 | 分子名称: | Epidermal growth factor receptor, N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide | 著者 | Yun, C.H, Eck, M.J. | 登録日 | 2013-07-20 | 公開日 | 2014-01-15 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.526 Å) | 主引用文献 | Structural, Biochemical, and Clinical Characterization of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations in Lung Cancer. Sci Transl Med, 5, 2013
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2RFD
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![BU of 2rfd by Molmil](/molmil-images/mine/2rfd) | Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide | 分子名称: | ERBB receptor feedback inhibitor 1, Epidermal growth factor receptor, SULFATE ION | 著者 | Zhang, X, Pickin, K.A, Bose, R, Jura, N, Cole, P.A, Kuriyan, J. | 登録日 | 2007-09-28 | 公開日 | 2007-12-04 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature, 450, 2007
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6VHP
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![BU of 6vhp by Molmil](/molmil-images/mine/6vhp) | Wild type EGFR in complex with LN2899 | 分子名称: | Epidermal growth factor receptor, N-{3-[(4-{4-(4-fluorophenyl)-2-[(2-methoxyethyl)sulfanyl]-1H-imidazol-5-yl}pyridin-2-yl)amino]-4-methoxyphenyl}propanamide | 著者 | Heppner, D.E, Eck, M.J. | 登録日 | 2020-01-10 | 公開日 | 2020-04-22 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors. J.Med.Chem., 63, 2020
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7SZ5
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![BU of 7sz5 by Molmil](/molmil-images/mine/7sz5) | Cryo-EM structure of the extracellular module of the full-length EGFR bound to TGF-alpha "tips-separated" conformation | 分子名称: | Epidermal growth factor receptor, Transforming growth factor alpha | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | 登録日 | 2021-11-25 | 公開日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
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8HGS
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![BU of 8hgs by Molmil](/molmil-images/mine/8hgs) | The EGF-bound EGFR ectodomain homodimer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, Pro-epidermal growth factor, ... | 著者 | Zhang, Z, Bai, X. | 登録日 | 2022-11-15 | 公開日 | 2023-02-15 | 最終更新日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (3.81 Å) | 主引用文献 | Structure and dynamics of the EGFR/HER2 heterodimer. Cell Discov, 9, 2023
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4LL0
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![BU of 4ll0 by Molmil](/molmil-images/mine/4ll0) | EGFR L858R/T790M in complex with PD168393 | 分子名称: | Epidermal growth factor receptor, N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide | 著者 | Yun, C.H, Eck, M.J. | 登録日 | 2013-07-09 | 公開日 | 2013-09-11 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (4 Å) | 主引用文献 | Mechanism for activation of mutated epidermal growth factor receptors in lung cancer. Proc.Natl.Acad.Sci.USA, 110, 2013
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8HGP
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![BU of 8hgp by Molmil](/molmil-images/mine/8hgp) | The EREG-bound EGFR/HER2 ectodomain complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, ... | 著者 | Zhang, Z, Bai, X. | 登録日 | 2022-11-15 | 公開日 | 2023-02-08 | 最終更新日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (4.53 Å) | 主引用文献 | Structure and dynamics of the EGFR/HER2 heterodimer. Cell Discov, 9, 2023
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7OM4
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![BU of 7om4 by Molmil](/molmil-images/mine/7om4) | |
2M0B
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![BU of 2m0b by Molmil](/molmil-images/mine/2m0b) | Homodimeric transmembrane domain of the human receptor tyrosine kinase ErbB1 (EGFR, HER1) in micelles | 分子名称: | Epidermal growth factor receptor | 著者 | Lesovoy, D.M, Bocharov, E.V, Pustovalova, Y.E, Bocharova, O.V, Arseniev, A.S. | 登録日 | 2012-10-24 | 公開日 | 2013-10-30 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Alternative packing of EGFR transmembrane domain suggests that protein-lipid interactions underlie signal conduction across membrane. Biochim. Biophys. Acta, 1858, 2016
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2M20
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![BU of 2m20 by Molmil](/molmil-images/mine/2m20) | EGFR transmembrane - juxtamembrane (TM-JM) segment in bicelles: MD guided NMR refined structure. | 分子名称: | Epidermal growth factor receptor | 著者 | Endres, N.F, Das, R, Smith, A, Arkhipov, A, Kovacs, E, Huang, Y, Pelton, J.G, Shan, Y, Shaw, D.E, Wemmer, D.E, Groves, J.T, Kuriyan, J. | 登録日 | 2012-12-11 | 公開日 | 2013-02-20 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor. Cell(Cambridge,Mass.), 152, 2013
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2N5S
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![BU of 2n5s by Molmil](/molmil-images/mine/2n5s) | |
1Z9I
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![BU of 1z9i by Molmil](/molmil-images/mine/1z9i) | |
5LV6
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![BU of 5lv6 by Molmil](/molmil-images/mine/5lv6) | N-terminal motif dimerization of EGFR transmembrane domain in bicellar environment | 分子名称: | Epidermal growth factor receptor | 著者 | Bragin, P, Bocharov, E, Mineev, K, Bocharova, O, Arseniev, A. | 登録日 | 2016-09-12 | 公開日 | 2017-04-05 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | The Conformation of the Epidermal Growth Factor Receptor Transmembrane Domain Dimer Dynamically Adapts to the Local Membrane Environment. Biochemistry, 56, 2017
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2KS1
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![BU of 2ks1 by Molmil](/molmil-images/mine/2ks1) | Heterodimeric association of Transmembrane domains of ErbB1 and ErbB2 receptors Enabling Kinase Activation | 分子名称: | Epidermal growth factor receptor, Receptor tyrosine-protein kinase erbB-2 | 著者 | Mineev, K.S, Bocharov, E.V, Pustovalova, Y.E, Bocharova, O.V, Chupin, V.V, Arseniev, A.S. | 登録日 | 2009-12-24 | 公開日 | 2010-06-09 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Spatial Structure of the Transmembrane Domain Heterodimer of ErbB1 and ErbB2 Receptor Tyrosine Kinases J.Mol.Biol., 2010
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