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4LL0

EGFR L858R/T790M in complex with PD168393

Summary for 4LL0
Entry DOI10.2210/pdb4ll0/pdb
Related4LRM
DescriptorEpidermal growth factor receptor, N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide (2 entities in total)
Functional Keywordskinase, pd168393, 34-jab, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains2
Total formula weight76155.62
Authors
Yun, C.H.,Eck, M.J. (deposition date: 2013-07-09, release date: 2013-09-11, Last modification date: 2023-09-20)
Primary citationRed Brewer, M.,Yun, C.H.,Lai, D.,Lemmon, M.A.,Eck, M.J.,Pao, W.
Mechanism for activation of mutated epidermal growth factor receptors in lung cancer.
Proc.Natl.Acad.Sci.USA, 110:E3595-E3604, 2013
Cited by
PubMed: 24019492
DOI: 10.1073/pnas.1220050110
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (4 Å)
Structure validation

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