4LL0
EGFR L858R/T790M in complex with PD168393
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Epidermal growth factor receptor | polymer | 331 | 37706.6 | 2 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1 |
| 2 | C, D (A, B) | N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide | non-polymer | 371.2 | 2 | Chemie (YUN) |
Sequence modifications
A, B: 694 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 692 | - | expression tag |
| Ser 693 | - | expression tag |
| Met 790 | Thr 790 | engineered mutation |
| Arg 858 | Leu 858 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75413.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 742.5 | |
| All* | Total formula weight | 76155.6 |
