4LL0

EGFR L858R/T790M in complex with PD168393

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Epidermal growth factor receptor	polymer	331	37706.6	2	UniProt (P00533) Pfam (PF07714) In PDB	Homo sapiens (human)	Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
2	A, B	N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide	non-polymer		371.2	2	Chemie (YUN)

Sequence modifications

A, B: 694 - 1022 (UniProt: P00533)

PDB	External Database	Details
Gly 692	-	expression tag
Ser 693	-	expression tag
Met 790	Thr 790	engineered mutation
Arg 858	Leu 858	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	75413.2
Non-Polymers*	Number of molecules	2
	Total formula weight	742.5
All*	Total formula weight	76155.6

*Water molecules are not included.