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2RFD

Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide

Summary for 2RFD
Entry DOI10.2210/pdb2rfd/pdb
Related2RF9 2RFE
DescriptorEpidermal growth factor receptor, ERBB receptor feedback inhibitor 1, SULFATE ION (3 entities in total)
Functional Keywordskinase domain, inhibition, dimer, alternative splicing, anti-oncogene, atp-binding, cell cycle, disease mutation, glycoprotein, membrane, nucleotide-binding, phosphorylation, polymorphism, receptor, secreted, transferase, transmembrane, tyrosine-protein kinase, ubl conjugation, cytoplasm
Biological sourceHomo sapiens (human)
More
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Cytoplasm : Q9UJM3
Total number of polymer chains4
Total formula weight79429.81
Authors
Zhang, X.,Pickin, K.A.,Bose, R.,Jura, N.,Cole, P.A.,Kuriyan, J. (deposition date: 2007-09-28, release date: 2007-12-04, Last modification date: 2023-08-30)
Primary citationZhang, X.,Pickin, K.A.,Bose, R.,Jura, N.,Cole, P.A.,Kuriyan, J.
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
Nature, 450:741-744, 2007
Cited by
PubMed: 18046415
DOI: 10.1038/nature05998
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.6 Å)
Structure validation

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