2RFD
Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Epidermal growth factor receptor | polymer | 324 | 36966.8 | 2 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Receptor tyrosine-protein kinase ErbB-1 |
| 2 | C, D (C, D) | ERBB receptor feedback inhibitor 1 | polymer | 25 | 2700.1 | 2 | UniProt (Q9UJM3) Pfam (PF11555) | Homo sapiens | Mitogen-inducible gene 6 protein, Mig-6 |
| 3 | E (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) |
Sequence modifications
A, B: 678 - 998 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 675 | - | expression tag |
| Ala 676 | - | expression tag |
| Met 677 | - | expression tag |
| Glu 799 | Lys 823 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 79333.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 96.1 | |
| All* | Total formula weight | 79429.8 |
