7SZ5
Cryo-EM structure of the extracellular module of the full-length EGFR bound to TGF-alpha "tips-separated" conformation
Summary for 7SZ5
Entry DOI | 10.2210/pdb7sz5/pdb |
EMDB information | 25561 |
Descriptor | Epidermal growth factor receptor, Transforming growth factor alpha (2 entities in total) |
Functional Keywords | receptor tyrosine kinases, epidermal growth factor receptor, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 279987.15 |
Authors | Huang, Y.,Ognjenovic, J.,Karandur, D.,Miller, K.,Merk, A.,Subramaniam, S.,Kuriyan, J. (deposition date: 2021-11-25, release date: 2021-12-22) |
Primary citation | Huang, Y.,Ognjenovic, J.,Karandur, D.,Miller, K.,Merk, A.,Subramaniam, S.,Kuriyan, J. A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10:-, 2021 Cited by PubMed: 34846302DOI: 10.7554/eLife.73218 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.6 Å) |
Structure validation
Download full validation report