2KS1
Heterodimeric association of Transmembrane domains of ErbB1 and ErbB2 receptors Enabling Kinase Activation
Summary for 2KS1
Entry DOI | 10.2210/pdb2ks1/pdb |
Related | 2jwa |
Descriptor | Receptor tyrosine-protein kinase erbB-2, Epidermal growth factor receptor (2 entities in total) |
Functional Keywords | erbb1, erbb2, transmembrane, heterodimer, complex, tyrosine kinase receptor, bicelles, transferase |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P04626 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: P00533 |
Total number of polymer chains | 2 |
Total formula weight | 9468.65 |
Authors | Mineev, K.S.,Bocharov, E.V.,Pustovalova, Y.E.,Bocharova, O.V.,Chupin, V.V.,Arseniev, A.S. (deposition date: 2009-12-24, release date: 2010-06-09, Last modification date: 2024-05-01) |
Primary citation | Mineev, K.S.,Bocharov, E.V.,Pustovalova, Y.E.,Bocharova, O.V.,Chupin, V.V.,Arseniev, A.S. Spatial Structure of the Transmembrane Domain Heterodimer of ErbB1 and ErbB2 Receptor Tyrosine Kinases J.Mol.Biol., 2010 Cited by PubMed: 20471394DOI: 10.1016/j.jmb.2010.05.016 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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