Homodimeric transmembrane domain of the human receptor tyrosine kinase ErbB1 (EGFR, HER1) in micelles

Summary for 2M0B

DescriptorEpidermal growth factor receptor (1 entity in total)
Functional Keywordstransmembrane domain, erbb1, receptor, dimerization, tyrosine kinase, membrane protein
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total molecular weight9467.7
Lesovoy, D.M.,Bocharov, E.V.,Pustovalova, Y.E.,Bocharova, O.V.,Arseniev, A.S. (deposition date: 2012-10-24, release date: 2013-10-30, Last modification date: 2019-06-26)
Primary citation
Bocharov, E.V.,Lesovoy, D.M.,Pavlov, K.V.,Pustovalova, Y.E.,Bocharova, O.V.,Arseniev, A.S.
Alternative packing of EGFR transmembrane domain suggests that protein-lipid interactions underlie signal conduction across membrane.
Biochim. Biophys. Acta, 1858:1254-1261, 2016
PubMed: 26903218 (PDB entries with the same primary citation)
DOI: 10.1016/j.bbamem.2016.02.023
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers190 0.2%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
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PDB entries from 2020-10-21