7LFS

Crystal structure of the epidermal growth factor receptor extracellular region with A265V mutation in complex with epiregulin

Summary for 7LFS

• Entry DOI: 10.2210/pdb7lfs/pdb
• Related: 7LEN
• Descriptor: Isoform 4 of Epidermal growth factor receptor, Proepiregulin, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: receptor, epiregulin, glioblastoma, cancer, mutation, extracellular, asymmetric, dimer, erbb1, egfr, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 253030.76

Authors

Hu, C.,Leche II, C.A.,Stayrook, S.E.,Ferguson, K.M.,Lemmon, M.A. (deposition date: 2021-01-18, release date: 2021-11-17, Last modification date: 2023-10-18)

• Primary citation: Hu, C.,Leche 2nd, C.A.,Kiyatkin, A.,Yu, Z.,Stayrook, S.E.,Ferguson, K.M.,Lemmon, M.A.; Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias.; Nature, 602:518-522, 2022; PubMed: 35140400; DOI: 10.1038/s41586-021-04393-3

Experimental method

X-RAY DIFFRACTION (3.5 Å)