7OM4

Nanobody EgB4 bound to the full extracellular EGFR-EGF complex

Summary for 7OM4

• Entry DOI: 10.2210/pdb7om4/pdb
• Descriptor: Epidermal growth factor receptor, Epidermal growth factor, Nanobody EgB4, ... (4 entities in total)
• Functional Keywords: egfr, nanobody, cancer, signaling, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 91682.24

Authors

Zeronian, M.R.,Janssen, B.J.C. (deposition date: 2021-05-21, release date: 2022-03-02, Last modification date: 2024-01-31)

• Primary citation: Zeronian, M.R.,Doulkeridou, S.,van Bergen En Henegouwen, P.M.P.,Janssen, B.J.C.; Structural insights into the non-inhibitory mechanism of the anti-EGFR EgB4 nanobody.; Bmc Mol Cell Biol, 23:12-12, 2022; PubMed: 35232398; DOI: 10.1186/s12860-022-00412-x

Experimental method

X-RAY DIFFRACTION (6.05 Å)