6VHP
Wild type EGFR in complex with LN2899
Summary for 6VHP
Entry DOI | 10.2210/pdb6vhp/pdb |
Descriptor | Epidermal growth factor receptor, N-{3-[(4-{4-(4-fluorophenyl)-2-[(2-methoxyethyl)sulfanyl]-1H-imidazol-5-yl}pyridin-2-yl)amino]-4-methoxyphenyl}propanamide (2 entities in total) |
Functional Keywords | egfr, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 37825.74 |
Authors | Heppner, D.E.,Eck, M.J. (deposition date: 2020-01-10, release date: 2020-04-22, Last modification date: 2023-10-11) |
Primary citation | Heppner, D.E.,Gunther, M.,Wittlinger, F.,Laufer, S.A.,Eck, M.J. Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors. J.Med.Chem., 63:4293-4305, 2020 Cited by PubMed: 32243152DOI: 10.1021/acs.jmedchem.0c00200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.6 Å) |
Structure validation
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