6CK2
 
 | | Insulin analog containing a YB26W mutation | | Descriptor: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | | Authors: | Rege, N.K, Yee, V.C, Weiss, M.A. | | Deposit date: | 2018-02-27 | | Release date: | 2018-06-13 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structure-based stabilization of insulin as a therapeutic protein assembly via enhanced aromatic-aromatic interactions.
J. Biol. Chem., 293, 2018
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6S34
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3FQ9
 | | Design of an insulin analog with enhanced receptor-binding selectivity. Rationale, structure, and therapeutic implications | | Descriptor: | Insulin, ZINC ION | | Authors: | Zhao, M, Wan, Z.L, Whittaker, L, Xu, B, Phillips, N, Katsoyannis, P, Whittaker, J, Weiss, M.A. | | Deposit date: | 2009-01-07 | | Release date: | 2009-08-04 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications.
J.Biol.Chem., 284, 2009
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6TYH
 | | Four-Disulfide Insulin Analog A22/B22 | | Descriptor: | ACETONE, CHLORIDE ION, GLYCEROL, ... | | Authors: | Blakely, A.D, Xiong, X. | | Deposit date: | 2019-08-08 | | Release date: | 2019-11-13 | | Last modified: | 2020-03-11 | | Method: | X-RAY DIFFRACTION (1.600019 Å) | | Cite: | Novel four-disulfide insulin analog with high aggregation stability and potency.
Chem Sci, 11, 2020
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3GF1
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3GKY
 | | The Structural Basis of an ER Stress-Associated Bottleneck in a Protein Folding Landscape | | Descriptor: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | | Authors: | Liu, M, Wan, Z.L, Chu, Y.C, Alddin, H, Klaproth, B, Weiss, M.A. | | Deposit date: | 2009-03-11 | | Release date: | 2009-03-24 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of a "nonfoldable" insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITY.
J.Biol.Chem., 284, 2009
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6INS
 | | X-RAY ANALYSIS OF THE SINGLE CHAIN B29-A1 PEPTIDE-LINKED INSULIN MOLECULE. A COMPLETELY INACTIVE ANALOGUE | | Descriptor: | INSULIN, ZINC ION | | Authors: | Derewenda, U, Derewenda, Z, Dodson, E.J, Dodson, G.G, Bing, X, Markussen, J. | | Deposit date: | 1992-11-25 | | Release date: | 1994-01-31 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | X-ray analysis of the single chain B29-A1 peptide-linked insulin molecule. A completely inactive analogue.
J.Mol.Biol., 220, 1991
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3I3Z
 | | Human insulin | | Descriptor: | Insulin A chain, Insulin B chain | | Authors: | Timofeev, V.I, Bezuglov, V.V, Miroshnikov, K.A, Cuprov-Netochin, R.N, Samigina, V.R, Kuranova, I.P. | | Deposit date: | 2009-07-01 | | Release date: | 2010-01-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | X-ray investigation of gene-engineered human insulin crystallized from a solution containing polysialic acid.
Acta Crystallogr.,Sect.F, 66, 2010
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6JR3
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3INC
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3INS
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3IR0
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3ILG
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6H3M
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6K59
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3I40
 | | Human insulin | | Descriptor: | Insulin A chain, Insulin B chain | | Authors: | Timofeev, V.I, Bezuglov, V.V, Miroshnikov, K.A, Chuprov-Netochin, R.N, Kuranova, I.P. | | Deposit date: | 2009-07-01 | | Release date: | 2010-01-05 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | X-ray investigation of gene-engineered human insulin crystallized from a solution containing polysialic acid.
Acta Crystallogr.,Sect.F, 66, 2010
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3JSD
 | | Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus | | Descriptor: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | | Authors: | Weiss, M.A, Wan, Z.L, Dodson, E.J, Liu, M, Xu, B, Hua, Q.X, Turkenburg, M, Whittingham, J, Nakagawa, S.H, Huang, K, Hu, S.Q, Jia, W.H, Wang, S.H, Brange, J, Whittaker, J, Arvan, P, Katsoyannis, P.G, Dodson, G.G. | | Deposit date: | 2009-09-10 | | Release date: | 2010-09-15 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
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6KH8
 | | Solution structure of Zn free Bovine Pancreatic Insulin in 20% acetic acid-d4 (pH 1.9) | | Descriptor: | Insulin A Chain, Insulin B chain | | Authors: | Bhunia, A, Ratha, B.N, Kar, R.K, Brender, J.R. | | Deposit date: | 2019-07-14 | | Release date: | 2020-10-07 | | Last modified: | 2020-11-18 | | Method: | SOLUTION NMR | | Cite: | High-resolution structure of a partially folded insulin aggregation intermediate.
Proteins, 88, 2020
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6KH9
 | | Solution structure of bovine insulin amyloid intermediate-1 | | Descriptor: | Insulin A chain, Insulin B chain | | Authors: | Ratha, B.N, Kar, R.K, Brender, J.B, Bhunia, A. | | Deposit date: | 2019-07-14 | | Release date: | 2020-08-12 | | Last modified: | 2024-10-09 | | Method: | SOLUTION NMR | | Cite: | High-resolution structure of a partially folded insulin aggregation intermediate.
Proteins, 88, 2020
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3TT8
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4I5Y
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1OS4
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4I5Z
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3U4N
 | | A novel covalently linked insulin dimer | | Descriptor: | Insulin A chain, Insulin B chain | | Authors: | Norrman, M, Vinther, T.N. | | Deposit date: | 2011-10-10 | | Release date: | 2012-04-11 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Novel covalently linked insulin dimer engineered to investigate the function of insulin dimerization.
Plos One, 7, 2012
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4IDW
 | | Polycrystalline T6 Bovine Insulin: Anisotropic Lattice Evolution and Novel Structure Refinement Strategy | | Descriptor: | Insulin A chain, Insulin B chain, ZINC ION | | Authors: | Margiolaki, I, Giannopoulou, A.E, Wright, J.P, Knight, L, Norrman, M, Schluckebier, G, Fitch, A, Von Dreele, R.B. | | Deposit date: | 2012-12-13 | | Release date: | 2013-06-05 | | Method: | POWDER DIFFRACTION | | Cite: | High-resolution powder X-ray data reveal the T6 hexameric form of bovine insulin
Acta Crystallogr.,Sect.D, 69, 2013
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