Crystal Structure of Human Insulin complexed with Cu+2 metal ion

Summary for 3IR0

Related2R36 2R34 2R35 1TRZ 1MSO 2QIU
DescriptorInsulin A chain, Insulin B chain, COPPER (II) ION, ... (4 entities in total)
Functional Keywordsinsulin, metal binding, coordination, confromation, bilogical role, carbohydrate metabolism, cleavage on pair of basic residues, diabetes mellitus, disease mutation, disulfide bond, glucose metabolism, hormone, secreted
Biological sourceHomo sapiens (human)
Cellular locationSecreted P01308 P01308
Total number of polymer chains24
Total molecular weight70574.36
Raghavendra, N.,Pattabhi, V.,Rajan, S.S. (deposition date: 2009-08-21, release date: 2010-09-01, Last modification date: 2011-07-13)
Primary citation
Raghavendra, N.,Pattabhi, V.,Rajan, S.S.
Metal induced structural changes observed in Human insulin
To be Published,
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliers0.326230.5%11.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution