6TYH

Four-Disulfide Insulin Analog A22/B22

Summary for 6TYH

Entry DOI	10.2210/pdb6tyh/pdb
Descriptor	Insulin A chain, Insulin B chain, PHENOL, ... (8 entities in total)
Functional Keywords	signalling, metabolism, hormone
Biological source	Homo sapiens (Human) More
Total number of polymer chains	12
Total formula weight	36361.31
Authors	Blakely, A.D.,Xiong, X. (deposition date: 2019-08-08, release date: 2019-11-13, Last modification date: 2020-03-11)
Primary citation	Xiong, X.,Blakely, A.,Karra, P.,VandenBerg, M.A.,Ghabash, G.,Whitby, F.,Zhang, Y.W.,Webber, M.J.,Holland, W.L.,Hill, C.P.,Chou, D.H. Novel four-disulfide insulin analog with high aggregation stability and potency. Chem Sci, 11:195-200, 2020 Cited by PubMed: 32110371 DOI: 10.1039/c9sc04555d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.60001899481 Å)

Structure validation