6TYH

Four-Disulfide Insulin Analog A22/B22

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G, I... (A, C, E, G, I...)	Insulin A chain	polymer	22	2486.8	6	UniProt (P01308)	Homo sapiens
2	B, D, F, H, J... (B, D, F, H, J...)	Insulin B chain	polymer	30	3379.9	6	UniProt (P01308) Pfam (PF00049)	Homo sapiens
3	M, R, T, U, V... (A, C, D, E, G...)	PHENOL	non-polymer		94.1	7	Chemie (IPH)
4	N, Q (A, B)	ACETONE	non-polymer		58.1	2	Chemie (ACN)
5	O, S (B, D)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
6	P, W (B, H)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
7	AA, Y (L, J)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
8	BA, CA, DA, EA, FA... (A, B, C, D, E...)	water	water		18.0	231	Chemie (HOH)

Sequence modifications

A, C, E, G, I, K: 1 - 21 (UniProt: P01308)

PDB	External Database	Details
Cys 22	-	engineered mutation

B, D, F, H, J, L: 1 - 30 (UniProt: P01308)

PDB	External Database	Details
Cys 22	Arg 46	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	35200.5
Non-Polymers*	Number of molecules	15
	Total formula weight	1160.8
All*	Total formula weight	36361.3

*Water molecules are not included.