6CK2

Insulin analog containing a YB26W mutation

Summary for 6CK2

• Entry DOI: 10.2210/pdb6ck2/pdb
• Descriptor: Insulin A chain, Insulin B chain, ZINC ION, ... (6 entities in total)
• Functional Keywords: long-acting, basal, therapeutic, peptide hormone, diabetes, biomolecular engineering, hormone
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 11911.69

Authors

Rege, N.K.,Yee, V.C.,Weiss, M.A. (deposition date: 2018-02-27, release date: 2018-06-13, Last modification date: 2023-10-04)

• Primary citation: Rege, N.K.,Wickramasinghe, N.P.,Tustan, A.N.,Phillips, N.F.B.,Yee, V.C.,Ismail-Beigi, F.,Weiss, M.A.; Structure-based stabilization of insulin as a therapeutic protein assembly via enhanced aromatic-aromatic interactions.; J. Biol. Chem., 293:10895-10910, 2018; PubMed: 29880646; DOI: 10.1074/jbc.RA118.003650

Experimental method

X-RAY DIFFRACTION (2.25 Å)