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7LS2
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BU of 7ls2 by Molmil
80S ribosome from mouse bound to eEF2 (Class I)
Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ...
Authors:Loerch, S, Smith, P.R, Kunder, N, Stanowick, A.D, Lou, T.-F, Campbell, Z.T.
Deposit date:2021-02-17
Release date:2021-11-03
Last modified:2021-12-08
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.
Nat Commun, 12, 2021
7LS1
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BU of 7ls1 by Molmil
80S ribosome from mouse bound to eEF2 (Class II)
Descriptor: 28S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
Authors:Loerch, S, Smith, P.R, Kunder, N, Stanowick, A.D, Lou, T.-F, Campbell, Z.T.
Deposit date:2021-02-17
Release date:2021-11-03
Last modified:2021-12-08
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.
Nat Commun, 12, 2021
7NBB
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BU of 7nbb by Molmil
Branched Lys48- and Lys63-linked tri-ubiquitin (K48-K63-Ub3) in complex with synthetic nanobody NbSL3
Descriptor: CHLORIDE ION, GLYCEROL, MAGNESIUM ION, ...
Authors:Lange, S.M, Kulathu, Y.
Deposit date:2021-01-26
Release date:2022-08-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Branched Lys48- and Lys63-linked tri-ubiquitin (K48-K63-Ub3) in complex with synthetic nanobody NbSL3
To Be Published
7BHP
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BU of 7bhp by Molmil
Cryo-EM structure of the human Ebp1 - 80S ribosome
Descriptor: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ...
Authors:Desogus, J, Bhaskar, V, Chao, J.A.
Deposit date:2021-01-11
Release date:2021-02-03
Last modified:2021-03-31
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Dynamic association of human Ebp1 with the ribosome.
Rna, 27, 2021
7BBD
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BU of 7bbd by Molmil
Crystal structure of monoubiquitinated TRIM21 RING (Ub-RING) In complex with ubiquitin charged Ube2N (Ube2N~Ub) and Ube2V2
Descriptor: Polyubiquitin-B,E3 ubiquitin-protein ligase TRIM21, Polyubiquitin-C, Ubiquitin-conjugating enzyme E2 N, ...
Authors:Kiss, L, Neuhaus, D, James, L.C.
Deposit date:2020-12-17
Release date:2021-01-27
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination.
Nat Commun, 12, 2021
7BBF
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BU of 7bbf by Molmil
Crystal structure of ubiquitin charged Ube2N (Ube2N~Ub) in complex with Ube2V2
Descriptor: Polyubiquitin-C, Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 2
Authors:Kiss, L, Neuhaus, D, James, L.C.
Deposit date:2020-12-17
Release date:2021-01-27
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination.
Nat Commun, 12, 2021
7DNI
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BU of 7dni by Molmil
MDA5 CARDs-MAVS CARD polyUb complex
Descriptor: Interferon-induced helicase C domain-containing protein 1, Mitochondrial antiviral-signaling protein, Ubiquitin
Authors:Song, B, Chen, Y, Luo, D.H, Zheng, J.
Deposit date:2020-12-09
Release date:2021-10-13
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains.
Immunity, 54, 2021
7DNJ
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BU of 7dnj by Molmil
K63-polyUb MDA5CARDs complex
Descriptor: Interferon-induced helicase C domain-containing protein 1, Ubiquitin
Authors:Song, B, Chen, Y, Luo, D.H, Zheng, J.
Deposit date:2020-12-09
Release date:2021-10-13
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains.
Immunity, 54, 2021
7B5N
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BU of 7b5n by Molmil
Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: NEDD8-CUL1-RBX1-UBE2L3~Ub~ARIH1.
Descriptor: 5-azanylpentan-2-one, Cullin-1, E3 ubiquitin-protein ligase ARIH1, ...
Authors:Horn-Ghetko, D, Prabu, J.R, Schulman, B.A.
Deposit date:2020-12-05
Release date:2021-02-10
Last modified:2021-03-10
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly.
Nature, 590, 2021
7B5M
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BU of 7b5m by Molmil
Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: CUL1-RBX1-SKP1-SKP2-CKSHS1-p27~Ub~ARIH1. Transition State 2
Descriptor: Cullin-1, Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinases regulatory subunit 1, ...
Authors:Horn-Ghetko, D, Prabu, J.R, Schulman, B.A.
Deposit date:2020-12-05
Release date:2021-02-17
Last modified:2021-03-10
Method:ELECTRON MICROSCOPY (3.91 Å)
Cite:Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly.
Nature, 590, 2021
7B5L
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BU of 7b5l by Molmil
Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: NEDD8-CUL1-RBX1-SKP1-SKP2-CKSHS1-Cyclin A-CDK2-p27-UBE2L3~Ub~ARIH1. Transition State 1
Descriptor: 5-azanylpentan-2-one, Cullin-1, Cyclin-A2, ...
Authors:Horn-Ghetko, D, Prabu, J.R, Schulman, B.A.
Deposit date:2020-12-04
Release date:2021-02-10
Last modified:2021-03-10
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly.
Nature, 590, 2021
7AZY
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BU of 7azy by Molmil
Context-specific inhibition of eukaryotic translation by macrolide antibiotics
Descriptor: 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ...
Authors:Koller, T.O, Wilson, D.N.
Deposit date:2020-11-17
Release date:2021-05-19
Last modified:2022-05-25
Method:ELECTRON MICROSCOPY (2.877 Å)
Cite:Context-specific action of macrolide antibiotics on the eukaryotic ribosome.
Nat Commun, 12, 2021
7AY2
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BU of 7ay2 by Molmil
Crystal structure of truncated USP1-UAF1 reacted with ubiquitin-prg
Descriptor: Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 1, WD repeat-containing protein 48, ...
Authors:Arkinson, C, Rennie, M.L, Walden, H.
Deposit date:2020-11-10
Release date:2021-03-24
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis of FANCD2 deubiquitination by USP1-UAF1.
Nat.Struct.Mol.Biol., 28, 2021
7AY1
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BU of 7ay1 by Molmil
Cryo-EM structure of USP1-UAF1 bound to mono-ubiquitinated FANCD2, and FANCI
Descriptor: DNA (61-MER), Fanconi anemia group D2 protein, Fanconi anemia group I protein, ...
Authors:Rennie, M.L, Arkinson, C, Walden, H.
Deposit date:2020-11-10
Release date:2021-03-24
Last modified:2022-07-27
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural basis of FANCD2 deubiquitination by USP1-UAF1.
Nat.Struct.Mol.Biol., 28, 2021
7ASE
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BU of 7ase by Molmil
43S preinitiation complex from Trypanosoma cruzi with the kDDX60 helicase
Descriptor: 18S, 40S ribosomal protein S10, putative, ...
Authors:Bochler, A, Brito Querido, J, Prilepskaja, T, Soufari, H, Del Cistia, M.L, Kuhn, L, Rimoldi Ribeiro, A, Valasek, L.S, Hashem, Y.
Deposit date:2020-10-27
Release date:2021-04-14
Last modified:2021-04-21
Method:ELECTRON MICROSCOPY (3.33 Å)
Cite:Structural Differences in Translation Initiation between Pathogenic Trypanosomatids and Their Mammalian Hosts.
Cell Rep, 33, 2020
7KHH
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BU of 7khh by Molmil
Ternary complex of VHL/BRD4-BD1/Compound9 (4-(3,5-difluoropyridin-2-yl)-N-(11-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-11-oxoundecyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-6-carboxamide)
Descriptor: Bromodomain-containing protein 4, Elongin-B, Elongin-C, ...
Authors:Murray, J.M.
Deposit date:2020-10-21
Release date:2021-02-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.281 Å)
Cite:Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy.
J.Med.Chem., 64, 2021
7KEO
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BU of 7keo by Molmil
Crystal structure of K29-linked di-ubiquitin in complex with synthetic antigen binding fragment
Descriptor: PHOSPHATE ION, Synthetic antigen binding fragment, heavy chain, ...
Authors:Yu, Y, Zheng, Q, Erramilli, S, Pan, M, Kossiakoff, A, Liu, L, Zhao, M.
Deposit date:2020-10-11
Release date:2021-07-28
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle.
Nat.Chem.Biol., 17, 2021
7AI0
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BU of 7ai0 by Molmil
Crystal structure of human MDM2-G443T RING domain homodimer bound to UbcH5B-Ub (Crystal form 1)
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ...
Authors:Magnussen, H.M, Huang, D.T.
Deposit date:2020-09-25
Release date:2021-01-20
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.559 Å)
Cite:Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant.
J.Mol.Biol., 433, 2021
7AHZ
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BU of 7ahz by Molmil
Crystal structure of Western clawed frog MDM2 RING domain homodimer bound to UbcH5B-Ub
Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, Polyubiquitin-B, ...
Authors:Magnussen, H.M, Huang, D.T.
Deposit date:2020-09-25
Release date:2021-01-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant.
J.Mol.Biol., 433, 2021
7AI1
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BU of 7ai1 by Molmil
Crystal structure of human MDM2-G443T RING domain homodimer bound to UbcH5B-Ub (Crystal form 2)
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ...
Authors:Magnussen, H.M, Huang, D.T.
Deposit date:2020-09-25
Release date:2021-01-20
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant.
J.Mol.Biol., 433, 2021
7K6Q
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BU of 7k6q by Molmil
Active state Dot1 bound to the H4K16ac nucleosome
Descriptor: DNA (146-MER), Histone H2A type 1, Histone H2B 1.1, ...
Authors:Valencia-Sanchez, M.I, De Ioannes, P.E, Miao, W, Truong, D.M, Lee, R, Armache, J.-P, Boeke, J.D, Armache, K.-J.
Deposit date:2020-09-21
Release date:2021-02-10
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Regulation of the Dot1 histone H3K79 methyltransferase by histone H4K16 acetylation.
Science, 371, 2021
7K6P
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BU of 7k6p by Molmil
Active state Dot1 bound to the unacetylated H4 nucleosome
Descriptor: DNA (146-MER), Histone H2A type 1, Histone H2B 1.1, ...
Authors:Valencia-Sanchez, M.I, De Ioannes, P.E, Miao, W, Truong, D.M, Lee, R, Armache, J.-P, Boeke, J.D, Armache, K.-J.
Deposit date:2020-09-21
Release date:2021-02-10
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Regulation of the Dot1 histone H3K79 methyltransferase by histone H4K16 acetylation.
Science, 371, 2021
7K5J
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BU of 7k5j by Molmil
Structure of an E1-E2-ubiquitin thioester mimetic
Descriptor: ADENOSINE MONOPHOSPHATE, Ubiquitin, Ubiquitin-activating enzyme E1 1, ...
Authors:Yuan, L, Lv, Z, Olsen, S.K.
Deposit date:2020-09-16
Release date:2021-04-28
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.42 Å)
Cite:Crystal structures of an E1-E2-ubiquitin thioester mimetic reveal molecular mechanisms of transthioesterification.
Nat Commun, 12, 2021
7K5I
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BU of 7k5i by Molmil
SARS-COV-2 nsp1 in complex with human 40S ribosome
Descriptor: 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ...
Authors:Wang, L, Shi, M, Wu, H.
Deposit date:2020-09-16
Release date:2020-10-14
Last modified:2021-03-17
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism.
Biorxiv, 2020
7ABG
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BU of 7abg by Molmil
Human pre-Bact-1 spliceosome
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Cell division cycle 5-like protein, ...
Authors:Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R.
Deposit date:2020-09-07
Release date:2020-12-23
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (7.8 Å)
Cite:Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation.
Science, 370, 2020

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