7AY1

Cryo-EM structure of USP1-UAF1 bound to mono-ubiquitinated FANCD2, and FANCI

Summary for 7AY1

• Entry DOI: 10.2210/pdb7ay1/pdb
• EMDB information: 11934
• Descriptor: Fanconi anemia group I protein, Fanconi anemia group D2 protein, Ubiquitin-60S ribosomal protein L40, ... (7 entities in total)
• Functional Keywords: deubiquitination, specificity, dna repair, fanconi anemia, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 7
• Total formula weight: 501070.06

Authors

Rennie, M.L.,Arkinson, C.,Walden, H. (deposition date: 2020-11-10, release date: 2021-03-24, Last modification date: 2022-07-27)

• Primary citation: Rennie, M.L.,Arkinson, C.,Chaugule, V.K.,Toth, R.,Walden, H.; Structural basis of FANCD2 deubiquitination by USP1-UAF1.; Nat.Struct.Mol.Biol., 28:356-364, 2021; PubMed: 33795880; DOI: 10.1038/s41594-021-00576-8

Experimental method

ELECTRON MICROSCOPY (3.7 Å)