Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7AY1

Cryo-EM structure of USP1-UAF1 bound to mono-ubiquitinated FANCD2, and FANCI

Functional Information from GO Data
ChainGOidnamespacecontents
A0000785cellular_componentchromatin
A0003677molecular_functionDNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006281biological_processDNA repair
A0016020cellular_componentmembrane
A0031398biological_processpositive regulation of protein ubiquitination
A0036297biological_processinterstrand cross-link repair
A0070182molecular_functionDNA polymerase binding
A1990391cellular_componentDNA repair complex
B0000785cellular_componentchromatin
B0000793cellular_componentcondensed chromosome
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005829cellular_componentcytosol
B0006281biological_processDNA repair
B0006974biological_processDNA damage response
B0007129biological_processhomologous chromosome pairing at meiosis
B0007276biological_processgamete generation
B0010332biological_processresponse to gamma radiation
B0016604cellular_componentnuclear body
B0031573biological_processmitotic intra-S DNA damage checkpoint signaling
B0034599biological_processcellular response to oxidative stress
B0036297biological_processinterstrand cross-link repair
B0045589biological_processregulation of regulatory T cell differentiation
B0048854biological_processbrain morphogenesis
B0050727biological_processregulation of inflammatory response
B0070182molecular_functionDNA polymerase binding
B0097150biological_processneuronal stem cell population maintenance
B1990391cellular_componentDNA repair complex
B1990918biological_processdouble-strand break repair involved in meiotic recombination
B2000348biological_processregulation of CD40 signaling pathway
D0001501biological_processskeletal system development
D0004197molecular_functioncysteine-type endopeptidase activity
D0004843molecular_functioncysteine-type deubiquitinase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005829cellular_componentcytosol
D0006281biological_processDNA repair
D0006282biological_processregulation of DNA repair
D0006508biological_processproteolysis
D0008233molecular_functionpeptidase activity
D0008234molecular_functioncysteine-type peptidase activity
D0009411biological_processresponse to UV
D0016579biological_processprotein deubiquitination
D0035520biological_processmonoubiquitinated protein deubiquitination
D0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
D1904333biological_processpositive regulation of error-prone translesion synthesis
E0000724biological_processdouble-strand break repair via homologous recombination
E0003677molecular_functionDNA binding
E0003690molecular_functiondouble-stranded DNA binding
E0003697molecular_functionsingle-stranded DNA binding
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005764cellular_componentlysosome
E0005768cellular_componentendosome
E0005770cellular_componentlate endosome
E0005829cellular_componentcytosol
E0006281biological_processDNA repair
E0006974biological_processDNA damage response
E0007283biological_processspermatogenesis
E0007338biological_processsingle fertilization
E0008584biological_processmale gonad development
E0035264biological_processmulticellular organism growth
E0035800molecular_functiondeubiquitinase activator activity
E0043130molecular_functionubiquitin binding
E0043231cellular_componentintracellular membrane-bounded organelle
E0043588biological_processskin development
E0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
E0048568biological_processembryonic organ development
E0048705biological_processskeletal system morphogenesis
E0048872biological_processhomeostasis of number of cells
E0050679biological_processpositive regulation of epithelial cell proliferation
E0072520biological_processseminiferous tubule development
E1902525biological_processregulation of protein monoubiquitination
E1905168biological_processpositive regulation of double-strand break repair via homologous recombination
Functional Information from PROSITE/UniProt
site_idPS00299
Number of Residues26
DetailsUBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD
ChainResidueDetails
CLYS27-ASP52

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LISAssDtTVKVWNA
ChainResidueDetails
ELEU90-ALA104
EVAL132-VAL146

site_idPS00973
Number of Residues19
DetailsUSP_2 Ubiquitin specific protease (USP) domain signature 2. YgLfAVvmHsGitiss.GHY
ChainResidueDetails
DTYR576-TYR594

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q8BH57
ChainResidueDetails
ETYR28
CARG72
BSER717
BSER1423

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ELYS214
BSER1404

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8BH57
ChainResidueDetails
ELYS578
ASER1121

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ETHR613
DSER313

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17525332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
DSER42

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
DSER67

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
DSER475
CGLY76

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8BJQ2
ChainResidueDetails
DSER768
CLYS48

site_idSWS_FT_FI9
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860
ChainResidueDetails
CLYS27

site_idSWS_FT_FI10
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127
ChainResidueDetails
CLYS29

site_idSWS_FT_FI11
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577
ChainResidueDetails
CLYS33

site_idSWS_FT_FI12
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106
ChainResidueDetails
CLYS63

222624

PDB entries from 2024-07-17

PDB statisticsPDBj update infoContact PDBjnumon