7DNI

MDA5 CARDs-MAVS CARD polyUb complex

Summary for 7DNI

• Entry DOI: 10.2210/pdb7dni/pdb
• EMDB information: 30784
• Descriptor: Ubiquitin, Interferon-induced helicase C domain-containing protein 1, Mitochondrial antiviral-signaling protein (3 entities in total)
• Functional Keywords: signaling, polyubiquitin, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 16
• Total formula weight: 209286.51

Authors

Song, B.,Chen, Y.,Luo, D.H.,Zheng, J. (deposition date: 2020-12-09, release date: 2021-10-13, Last modification date: 2022-02-16)

• Primary citation: Song, B.,Chen, Y.,Liu, X.,Yuan, F.,Tan, E.Y.J.,Lei, Y.,Song, N.,Han, Y.,Pascal, B.D.,Griffin, P.R.,Luo, C.,Wu, B.,Luo, D.,Zheng, J.; Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains.; Immunity, 54:2218-, 2021; PubMed: 34644557; DOI: 10.1016/j.immuni.2021.09.008

Experimental method

ELECTRON MICROSCOPY (3.2 Å)