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6NYB
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BU of 6nyb by Molmil
Structure of a MAPK pathway complex
Descriptor: 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Park, E, Rawson, S, Li, K, Jeon, H, Eck, M.J.
Deposit date:2019-02-11
Release date:2019-10-09
Last modified:2020-04-22
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
Nature, 575, 2019
6NV2
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BU of 6nv2 by Molmil
14-3-3 sigma with RelA/p65 binding site pS45 in complex with DP005
Descriptor: (4R,5R,6R,6aS,9S,9aE,10aR)-5-hydroxy-9-(methoxymethyl)-6,10a-dimethyl-3-(propan-2-yl)-1,2,4,5,6,6a,7,8,9,10a-decahydrodicyclopenta[a,d][8]annulen-4-yl alpha-D-glucopyranoside, 14-3-3 protein sigma, CHLORIDE ION, ...
Authors:Wolter, M, Ottmann, C.
Deposit date:2019-02-04
Release date:2020-05-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products.
J.Am.Chem.Soc., 142, 2020
6QK8
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BU of 6qk8 by Molmil
Crystal structure of yeast 14-3-3 protein (Bmh1) from Saccharomyces cerevisiae with the Nha1p (yeast Na+/H+ antiporter) 14-3-3 binding motif Ser481
Descriptor: Na(+)/H(+) antiporter, Protein BMH1
Authors:Smidova, A, Obsil, T, Obsilova, V.
Deposit date:2019-01-28
Release date:2019-10-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.917 Å)
Cite:The activity of Saccharomyces cerevisiae Na+, K+/H+antiporter Nha1 is negatively regulated by 14-3-3 protein binding at serine 481.
Biochim Biophys Acta Mol Cell Res, 1866, 2019
6QIU
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BU of 6qiu by Molmil
Crystal structure of 14-3-3 sigma in complex with Ataxin-1 Ser776 phosphopeptide
Descriptor: 14-3-3 protein sigma, Ataxin-1 phosphopeptide, CHLORIDE ION, ...
Authors:Leysen, S, Milroy, L.G, Davis, J.M, Brunsveld, L, Ottmann, C.
Deposit date:2019-01-21
Release date:2020-05-13
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Structural insights into the cytoplasmic chaperone effect of 14-3-3 proteins on Ataxin-1
To Be Published
6QHM
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BU of 6qhm by Molmil
14-3-3 sigma with RelA/p65 binding site pS281
Descriptor: 14-3-3 protein sigma, LEU-SEP-GLU
Authors:Wolter, M, Ottmann, C.
Deposit date:2019-01-16
Release date:2020-05-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products.
J.Am.Chem.Soc., 142, 2020
6QHL
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BU of 6qhl by Molmil
14-3-3 sigma with RelA/p65 binding site pS45
Descriptor: 14-3-3 protein sigma, GLYCEROL, Transcription factor p65
Authors:Wolter, M, Ottmann, C.
Deposit date:2019-01-16
Release date:2020-05-13
Last modified:2020-12-30
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products.
J.Am.Chem.Soc., 142, 2020
6QDU
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BU of 6qdu by Molmil
Crystal structure of 14-3-3sigma in complex with a RapGef2 pT740 phosphopeptide inhibited by semi-synthetic fusicoccane FC-NCPC
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FC-NCPC, ...
Authors:Andrei, S.A, Kaplan, A, Fournier, A.E, Ottman, C.
Deposit date:2019-01-02
Release date:2020-01-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.632 Å)
Cite:Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth.
Cell Chem Biol, 27, 2020
6QDT
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BU of 6qdt by Molmil
Crystal structure of 14-3-3sigma in complex with a RapGef2 pT740 phosphopeptide
Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
Authors:Andrei, S.A, Kaplan, A, Fournier, A.E, Ottman, C.
Deposit date:2019-01-02
Release date:2020-01-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.702 Å)
Cite:Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth.
Cell Chem Biol, 27, 2020
6QDS
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BU of 6qds by Molmil
Crystal structure of 14-3-3sigma in complex with a PAK6 pT99 phosphopeptide stabilized by semi-synthetic fusicoccane FC-NCPC
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FC-NCPC, ...
Authors:Andrei, S.A, Kaplan, A, Fournier, A.E, Ottman, C.
Deposit date:2019-01-02
Release date:2020-01-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth.
Cell Chem Biol, 27, 2020
6QDR
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BU of 6qdr by Molmil
Crystal structure of 14-3-3sigma in complex with a PAK6 pT99 phosphopeptide
Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
Authors:Andrei, S.A, Kaplan, A, Fournier, A.E, Ottman, C.
Deposit date:2019-01-02
Release date:2020-01-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.615 Å)
Cite:Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth.
Cell Chem Biol, 27, 2020
6HN2
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BU of 6hn2 by Molmil
Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 5
Descriptor: 14-3-3 protein sigma, 2-(3,4-dichlorophenyl)-~{N}-(2-sulfanylethyl)ethanamide, Estrogen Receptor, ...
Authors:Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C.
Deposit date:2018-09-13
Release date:2019-02-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers.
J. Am. Chem. Soc., 141, 2019
6HMT
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BU of 6hmt by Molmil
Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 2
Descriptor: 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, Estrogen Receptor, ...
Authors:Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C.
Deposit date:2018-09-12
Release date:2019-02-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers.
J. Am. Chem. Soc., 141, 2019
6HMU
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BU of 6hmu by Molmil
Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C45 mutant bound to disulfide fragment PPI stabilizer 6
Descriptor: 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(3-sulfanylpropyl)propanamide, Estrogen receptor, ...
Authors:Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C.
Deposit date:2018-09-12
Release date:2019-02-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers.
J. Am. Chem. Soc., 141, 2019
6HKB
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BU of 6hkb by Molmil
Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 3
Descriptor: (1~{R},2~{S})-2-[methyl-[(~{R})-(2-methylpropan-2-yl)oxy-oxidanyl-methyl]amino]-2-phenyl-1-(2-sulfanylethylamino)ethanol, 14-3-3 protein sigma, Estrogen receptor, ...
Authors:Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C.
Deposit date:2018-09-06
Release date:2019-02-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers.
J. Am. Chem. Soc., 141, 2019
6HKF
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BU of 6hkf by Molmil
Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 4
Descriptor: (1~{S})-2,2-diphenyl-1-(2-sulfanylethylamino)propan-1-ol, 14-3-3 protein sigma, Estrogen receptor, ...
Authors:Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C.
Deposit date:2018-09-06
Release date:2019-02-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers.
J. Am. Chem. Soc., 141, 2019
6HHP
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BU of 6hhp by Molmil
Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 1
Descriptor: (1~{R})-2-(4-chloranylphenoxy)-2-methyl-1-[methyl(2-sulfanylethyl)amino]propan-1-ol, 14-3-3 protein sigma, Estrogen receptor, ...
Authors:Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C.
Deposit date:2018-08-28
Release date:2019-02-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers.
J. Am. Chem. Soc., 141, 2019
6HEP
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BU of 6hep by Molmil
Crystal structure of human 14-3-3 beta in complex with CFTR R-domain peptide pS753-pS768
Descriptor: 14-3-3 protein beta/alpha, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Cystic fibrosis transmembrane conductance regulator
Authors:Stevers, L.M, Ottmann, C, Brunsveld, L.
Deposit date:2018-08-20
Release date:2018-10-24
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:A Thermodynamic Model for Multivalency in 14-3-3 Protein-Protein Interactions.
J. Am. Chem. Soc., 140, 2018
6EF5
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BU of 6ef5 by Molmil
14-3-3 with peptide
Descriptor: 14-3-3 protein zeta/delta, ARG-SER-LEU-SEP-ALA-PRO-GLY, LYS-LEU-SEP-LEU-GLN
Authors:Dhagat, U, Langendorf, C.G, Parker, M.W.P, Oakhill, J.S, Scott, J.W.
Deposit date:2018-08-16
Release date:2019-10-30
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:14-3-3 with peptide
To Be Published
6A5Q
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BU of 6a5q by Molmil
Structure of 14-3-3 beta in complex with TFEB 14-3-3 binding motif
Descriptor: 14-3-3 protein beta/alpha, MALONIC ACID, TFEB pS211-peptide
Authors:Xu, Y, Ren, J.Q, Feng, W.
Deposit date:2018-06-25
Release date:2019-02-13
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization.
Autophagy, 15, 2019
6A5S
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BU of 6a5s by Molmil
Structure of 14-3-3 gamma in complex with TFEB 14-3-3 binding motif
Descriptor: 14-3-3 protein gamma, MAGNESIUM ION, SODIUM ION, ...
Authors:Xu, Y, Ren, J.Q, Feng, W.
Deposit date:2018-06-25
Release date:2019-02-13
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization.
Autophagy, 15, 2019
6GNK
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BU of 6gnk by Molmil
Exoenzyme S from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, trimeric crystal form bound to Carba-NAD
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 14-3-3 protein beta/alpha, CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Karlberg, T, Pinto, A.F, Hornyak, P, Thorsell, A.G, Nareoja, K, Schuler, H.
Deposit date:2018-05-31
Release date:2018-09-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface.
Nat Commun, 9, 2018
6GNJ
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BU of 6gnj by Molmil
Exoenzyme S from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, trimeric crystal form in complex with STO1101
Descriptor: 14-3-3 protein beta/alpha, 3-(12-oxidanylidene-7-thia-9,11-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(8),2(6),9-trien-10-yl)propanoic acid, Exoenzyme S
Authors:Karlberg, T, Pinto, A.F, Hornyak, P, Thorsell, A.G, Nareoja, K, Schuler, H.
Deposit date:2018-05-31
Release date:2018-09-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface.
Nat Commun, 9, 2018
6GNN
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BU of 6gnn by Molmil
Exoenzyme T from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, tetrameric crystal form bound to STO1101
Descriptor: 14-3-3 protein beta/alpha, 3-(12-oxidanylidene-7-thia-9,11-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(8),2(6),9-trien-10-yl)propanoic acid, Exoenzyme T
Authors:Karlberg, T, Pinto, A.F, Hornyak, P, Thorsell, A.G, Nareoja, K, Schuler, H.
Deposit date:2018-05-31
Release date:2018-09-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.79 Å)
Cite:14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface.
Nat Commun, 9, 2018
6GN8
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BU of 6gn8 by Molmil
Exoenzyme S from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, trimeric crystal form
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 14-3-3 protein beta/alpha, Exoenzyme S
Authors:Karlberg, T, Pinto, A.F, Hornyak, P, Thorsell, A.G, Nareoja, K, Schuler, H.
Deposit date:2018-05-30
Release date:2018-09-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface.
Nat Commun, 9, 2018
6GN0
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BU of 6gn0 by Molmil
Exoenzyme S from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, tetrameric crystal form
Descriptor: 14-3-3 protein beta/alpha, Exoenzyme S
Authors:Karlberg, T, Pinto, A.F, Hornyak, P, Nareoja, K, Schuler, H.
Deposit date:2018-05-29
Release date:2018-09-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface.
Nat Commun, 9, 2018

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