6QHM

14-3-3 sigma with RelA/p65 binding site pS281

Summary for 6QHM

• Entry DOI: 10.2210/pdb6qhm/pdb
• Descriptor: 14-3-3 protein sigma, LEU-SEP-GLU (3 entities in total)
• Functional Keywords: 14-3-3, 14-3-3 sigma, p65, rela, peptide binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 29872.18

Authors

Wolter, M.,Ottmann, C. (deposition date: 2019-01-16, release date: 2020-05-13, Last modification date: 2024-01-24)

• Primary citation: Wolter, M.,de Vink, P.,Neves, J.F.,Srdanovic, S.,Higuchi, Y.,Kato, N.,Wilson, A.,Landrieu, I.,Brunsveld, L.,Ottmann, C.; Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products.; J.Am.Chem.Soc., 142:11772-11783, 2020; PubMed: 32501683; DOI: 10.1021/jacs.0c02151

Experimental method

X-RAY DIFFRACTION (1.25 Å)