6HMU

Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C45 mutant bound to disulfide fragment PPI stabilizer 6

Summary for 6HMU

• Entry DOI: 10.2210/pdb6hmu/pdb
• Descriptor: 14-3-3 protein sigma, Estrogen receptor, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: protein-protein interactions, fragment, tethering, stabilizer, protein binding
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 27777.19

Authors

Sijbesma, E.,Hallenbeck, K.K.,Leysen, S.,Arkin, M.R.,Ottmann, C. (deposition date: 2018-09-12, release date: 2019-02-27, Last modification date: 2024-01-24)

• Primary citation: Sijbesma, E.,Hallenbeck, K.K.,Leysen, S.,de Vink, P.J.,Skora, L.,Jahnke, W.,Brunsveld, L.,Arkin, M.R.,Ottmann, C.; Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers.; J. Am. Chem. Soc., 141:3524-3531, 2019; PubMed: 30707565; DOI: 10.1021/jacs.8b11658

Experimental method

X-RAY DIFFRACTION (1.2 Å)